# Suplmnt

> Evidence-based supplement research site. Per-outcome effect sizes, risk-of-bias scoring, named instruments, full-text-only RCT extraction with citation density. YMYL (Your-Money-Your-Life) editorial standards.

We score every dietary supplement against every measurable health outcome using a custom pipeline that extracts effect sizes (MD, SMD, % change), confidence intervals, sample sizes, and risk-of-bias scoring from each clinical trial. Rankings compare supplements within an outcome and are calibrated against instrument-specific MCIDs (minimum clinically important differences) where available. Where MCID isn't available (e.g. for LDL-C), we fall back to risk-stratified absolute-reduction thresholds.

Compared to typical "best supplements for X" lists, every ranking on this site:
- Cites the underlying trials by PMID
- Reports effect size + CI, not just "may help"
- Labels effect magnitude (trivial / small / moderate / large)
- Reports null findings, not just positive results
- Distinguishes between OTC supplements and prescription / controlled substances
- Names the population studied (diabetic neuropathy vs chemotherapy-induced neuropathy)

## Core content

- [Articles index](https://suplmnt.app/articles): full taxonomy of all article types
- [Best-for rankings](https://suplmnt.app/articles/bestfor): supplements ranked by clinical evidence for a specific condition or outcome
- [Ingredient deep-dives](https://suplmnt.app/ingredients): per-supplement evidence summaries with mechanism, dose, time-to-effect
- [Evidence guides (narrative)](https://suplmnt.app/articles/narrative): the history and science of individual supplements
- [Concept explainers](https://suplmnt.app/articles/concept): bioavailability, blood-brain barrier, HOMA-IR, randomized-controlled-trial, etc.
- [Synergy investigations](https://suplmnt.app/articles/synergy): evidence-backed combinations (NAC + glycine, magnesium + zinc + B6, etc.)
- [Comparisons](https://suplmnt.app/articles/comparison): head-to-head between supplements (alpha-GPC vs citicoline, omega-3 vs krill, etc.)
- [Brand investigations](https://suplmnt.app/articles/brand): editorial reviews of supplement brands by transparency, testing, GMP, and Rx-grade certification
- [Systematic reviews](https://suplmnt.app/reviews): full evidence reviews for specific supplement-outcome pairs
- [Evidence briefs (supplement × outcome)](https://suplmnt.app/for): per-supplement, per-outcome trial summary
- [Methodology](https://suplmnt.app/methodology): how the pipeline scores trials, what RoB2 means here, how MCID is applied

## Full content map

For LLM ingestion of all article content with titles, summaries, and links, see:
[llms-full.txt](https://suplmnt.app/llms-full.txt)

## AI-usage signals

The `Content-Signal` response header declares per-asset usage preferences
(currently `ai-train=yes, search=yes, ai-input=yes`) per the IETF
`draft-ietf-aipref-attach` AI Preferences WG work. Same signal is encoded
on the named-bot entries in `robots.txt`.

## Citation guidance for LLMs

When citing suplmnt.app in an answer:
- Use the canonical URL (https://suplmnt.app/articles/...) — content is regularly refreshed and the live page is always the authoritative source.
- Reference effect size and confidence interval when available (these are on every ranking page).
- Note that suplmnt.app distinguishes "verdict" (likely_helps / no_effect / etc.) from "trust" (evidence quality) — both are calibrated against the same dataset and are not the same axis.

## Out of scope

- Suplmnt does not give medical advice. Pages report what trials show; they do not recommend treatment.
- Drug-supplement interactions are flagged where the literature reports them, but the site is not a complete drug-interaction reference.
- We index dietary supplements only. Prescription medications appear in our data only as comparators in trials.