Lycopene

Lycopene

Best for

Raise protective carotenoid levels

Likely strong benefit · 7–70 mg/day for 0–26 weeks · 2 meta-analyses , n=1.1k

37 papers · 2 claims · 59 outcomes scored · 1 positive

Evidence summary

Evidence summary

Likely strong benefit

Lycopene shows a likely strong benefit for raising blood carotenoid levels, but healthy-adult skin elasticity trials do not support a visible skin-firming payoff.

  • Across 15 studies (n=1,104), lycopene raised blood lycopene and carotenoid markers, above the noticeable-change threshold.2
  • The full evidence base includes 37 papers and 59 outcomes, with the clearest signal in blood biomarkers.
  • Healthy-adult skin elasticity trials did not show a meaningful improvement.

Outcomes

What lycopene actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Raise protective carotenoid levels Likely strong benefit

Plant pigments reach your bloodstream and protect cells from oxidation.

15 meta-analyses n=1.1k 7–70 mg 0–26 wk #1/7
Build firmer, denser skin Probably doesn't help

More collagen density for skin that bounces back and holds its shape.

1 meta-analysis n=162 10–16 mg

Forms & standardisation

The best-covered forms in human studies are tomato products and standard lycopene extracts, not random blended greens powders.12 On a label, look for the actual lycopene amount in milligrams, because that number matters more than the marketing name. Products that come with food fat, or that you take with a meal, fit the absorption data better than dry pills taken alone.1

Risk profile

Adverse events and known drug interactions

Safety events

hepatitis E (acute viral hepatitis) severe
pulmonary embolus severe
increased bowel movements mild
minor adverse events mild
sinusitis mild
nausea mild
diarrhea / increased stool frequency mild
stomach pain / abdominal cramps mild

Drug interactions

Ethanol (Alcohol) major increases toxicity
Ethanol (Alcohol) moderate increases concentration
Colistin moderate decreases effect
Cisplatin moderate decreases effect
Docetaxel moderate increases concentration

Frequently asked

Common questions

What does lycopene actually do?

The clearest human-trial win is that it raises blood carotenoid levels, which tells you your body absorbs it and moves it into circulation.12 That is the most solidly proven effect, not a vague wellness claim.

Should you take lycopene with food?

Yes, take it with food, ideally a meal that has some fat. Tomato-based meals and capsules taken with a meal match the way lycopene absorbs best in human studies.1

Does lycopene tighten skin?

No meaningful skin-firming effect shows up in the available trial data. The one skin elasticity study did not deliver a real win.3

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