Clinical trials and meta-analyses, translated into decisions you can actually use.
700+ supplements · 11,000+ studies · 0 affiliate links
New Buying guide · Sep 25, 2026
Glutathione is often sold as an upgrade ladder: capsule, liposomal, then IV. The real question is whether higher delivery justifies higher cost and higher hassle.
883 words · 5 sources How we score →
Read the perspectiveNew Myth vs evidence Sep 23, 2026
Glutathione sits in a strange supplement category: biologically important, commercially overpromised, and backed by small human trials that are easier to exaggerate than interpret.
New Myth vs evidence Sep 21, 2026
That half used tub in the pantry raises a fair question. The answer depends less on the printed date and more on moisture, storage, and the form of creatine.
New evidence maps
Explore the supplements, outcomes, and trials studied across four high-interest health topics.
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New Explainer · biomarker Sep 1, 2026
IL-6 is an immune signal that rises when the body is responding to stress.
biomarker
New Explainer · biomarker Sep 1, 2026
TNF-alpha is an immune signal that turns inflammation on fast.
biomarker
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New Evidence guide May 28, 2026
Less joint pain and stiffness, reduced inflammation, gentler mood support, and quicker muscle recovery
Curcumin Promising 1,128 words · 17 sources · 5 min read
Read the guideNew Stack analysis May 27, 2026
Vitamin B Complex + Omega-3 is not just a random brain stack, but it is also not proven for everyone. The best signal comes from VITACOG analyses showing that B vitamins helped cognition and brain atrophy mainly when omega-3 status was high, plus OmegAD showing omega-3 worked better when homocysteine was lower, a marker of better B vitamin status. The only large factorial trial that gave both B vitamins and omega-3 together, SU.FOL.OM3, found no overall cognitive benefit, likely because it used dietary-level doses, only tested cognition at the end, and studied a cardiovascular population rather than a memory-decline population. Practical takeaway: this combo is most rational when lab work shows high homocysteine, low B12 or folate, low omega-3 index, low fish intake, or mild cognitive impairment risk, not as a blanket upgrade for already well-nourished adults.
Vitamin B Complex + Omega-3 Emerging 2 ingredients · 14 sources
Read the synergyNew Systematic review May 25, 2026
Berberine is most likely to help with blood sugar, not to dramatically change cholesterol. Across the studies reviewed here, the best-supported effects were lower fasting glucose, lower HbA1c, and better post-meal glucose control. Cholesterol and triglycerides often improved too, but usually by smaller amounts, and HDL, the so-called protective cholesterol, did not meaningfully improve. The evidence does not strongly support the idea that berberine works by making your pancreas pump out more insulin all the time. It seems more likely to improve how the body handles glucose overall. If you are considering berberine for metabolic health, the clearest reason is blood sugar support. Expect a moderate improvement if it works for you, not a miracle, and do not count on it as a major cholesterol solution.
12 papers Moderate certainty 12 papers · 1,828 participants · 12 outcomes
Read the reviewMore recent
New Guide May 24, 2026
Stone, Fire, and a Food That Fortified a Continent: The Real Story of Calcium
Stronger bones, safer pregnancies, and heart rhythm support when dietary intake falls short
Calcium
New Comparison May 19, 2026
Turmeric Whole Root vs Standardized Curcumin for Everyday Wellness and Targeted Joint Support
The choice matters because turmeric keeps you in food-first territory, while standardized curcumin moves you into supplement dosing with clearer label control and stronger joint evidence. What you give up or gain is the tradeoff between everyday cooking use, targeted support, and the extra safety and quality questions that come with concentrated products.
Health-conscious readers choosing between kitchen turmeric and targeted curcumin supplements
New Brief May 17, 2026
Vitamin D for Lower Systolic BP: What 9 Trials Show
Vitamin D does lower systolic blood pressure, but only by 0.7 mmHg on average across 9 studies in 4,952 people. The available reports here do not pin down a precise range around that average, and the effect sits far below the 5.0 mmHg smallest change people usually notice—more like a tiny nudge than a real-world shift.
9 studies
New Ranking May 17, 2026
Best Supplements to Ease ADHD Symptoms in Children (2026)
Most ADHD supplement lists copy hype from social media or affiliate blogs. This one ranks only what the clinical evidence actually supports for overall symptom severity in children, and it tells you where the data stays thin.
#1: Omega-3
New Brief May 15, 2026
Ashwagandha for Women's Sexual Function: What 8 Studies Show
Ashwagandha suggests a noticeable improvement in women's sexual function over about 8 weeks. Across 8 studies involving 239 participants, sexual-function scores rose by 11.84 points; the published combined estimate here does not pin down a precise range around that average, but the gain works out to 2.96 times the 4.0-point smallest change people usually notice—about three times that threshold.
8 studies
New Comparison May 14, 2026
Astaxanthin vs Lutein with Zeaxanthin for Eye Antioxidant Support
This choice matters because one option is built around macular pigment and AREDS2 style retina support, while the other is aimed more at screen strain and dry eye comfort. The real tradeoff is whether you want the better established eye formula for long term retinal support, or the carotenoid with the closer fit for daily visual fatigue.
Health-conscious supplement buyers comparing eye antioxidants for macular support, screen-heavy lifestyles, and age-related eye health
New Ranking · May 17, 2026
We ranked the top supplements for child ADHD symptoms using 9 clinical trials, with evidence, cautions, and honest notes on what works best.
3 ranked · 9 trials analyzed
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New Ranking · Apr 4, 2026
Collagen peptides top our evidence-ranked list of skin hydration supplements, backed by 13 trials and three meta-analyses. Oral HA and astaxanthin follow.
3 ranked · 29 trials analyzed
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New Ranking · Apr 4, 2026
Berberine tops our evidence-ranked list of fatty liver supplements. 26 supplements scored across 29 trials measuring liver fat directly.
7 ranked · 29 trials analyzed
Read the full ranking
New Ranking · Apr 4, 2026
Lycopene tops our evidence-ranked list of blood pressure supplements, followed by taurine and quercetin. We scored 130 supplements across 311 endpoints.
9 ranked · 311 trials analyzed
Read the full rankingSystematic Evidence Reviews
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