Visual research

Nutrient interactions, mapped.

A map of the relationships that change what your body absorbs, activates, or carries forward. Follow an arrow to see the mechanism, the conditions, and the source behind it.

21 factors 18 directed relationships 10 primary sources

Interaction map

What changes what

18 source-backed relationships

Supports absorption Can reduce absorption Metabolism or pathway
Calcium Caffeine Copper Dietary fat Iron Magnesium Nonheme iron Selenium Vitamin C Vitamin D Zinc Iodine Levothyroxine Metformin Oxalate Phosphorus Phytate Proton-pump inhibitor Vitamin B12 Vitamin E Vitamin K
The source nutrient can reduce intestinal absorption of the target nutrient under the stated conditions.

Zinc Copper

High supplemental zinc inhibits intestinal copper absorption and can lower copper status over time.

  • ODS identifies 50 mg/day or more for weeks as the relevant high supplemental zinc exposure.
  • This does not describe ordinary zinc intake from food.

Sources NIH Office of Dietary Supplements · NIH Office of Dietary Supplements

Source-backed relationships relevant to orally consumed nutrients, dietary factors, supplements, and medicines that directly affect nutrient absorption or metabolism. A mapping describes an interaction; it does not establish that the two nutrients should be co-supplemented.

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