Aescin
Best for
Reduce leg swelling during travel
Likely real but unnoticeable · 1 meta-analysis , n=502
1 papers · 2 claims · 1 outcomes scored · 2 positive
Outcomes
What aescin actually does, by outcome
Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.
Outcome Effect size Evidence Dose Weeks Rank
Reduce leg swelling during travel Likely real but unnoticeable
Keeps ankles and calves from puffing up on long flights or drives.
1 meta-analysis n=502 — — #2/2
1 meta-analysis
n=502
Meta-analyzed
—
—
#2 /2
Ease heavy, swollen legs Likely real but unnoticeable
Less swelling and heaviness from blood pooling in your leg veins.
1 meta-analysis n=502 — — #2/2
1 meta-analysis
n=502
Meta-analyzed
—
—
#2 /2
| Outcome | Effect | Evidence | Dose | Weeks | Rank |
|---|---|---|---|---|---|
| Reduce leg swelling during travel Likely real but unnoticeable | | 1 meta-analysis n=502 Meta-analyzed | — | — | #2/2 |
| Ease heavy, swollen legs Likely real but unnoticeable | | 1 meta-analysis n=502 Meta-analyzed | — | — | #2/2 |
Risk profile
Adverse events and known drug interactions
Safety events
gastrointestinal adverse events
constipation
dry mouth
gastrointestinal complaints
dizziness
nausea
headache
pruritus
Drug interactions
Cisplatin moderate additive
Warfarin minor increases effect
Sources
Generated August 14, 2026