Evidence map
Updated
Stress
Explore clinical evidence across the ways people experience stress, anxiety, and recovery.
Ingredients
46
Outcomes
7
Trials
127
Evidence map
Evidence across stress
Benefit Mixed / early No clear benefit Harm Not studied
Stress evidence map Reduce daily stress
| Stress Ingredient | Reduce daily stress | Reduce anxiety symptoms | Lower day-to-day anxiety | Feel calmer and more confident | Lower stress load | Reduce stress-hormone load | Restore healthy cortisol rhythm |
|---|---|---|---|---|---|---|---|
| 5-HTP | |||||||
| affron | |||||||
| Ashwagandha | |||||||
| Bacognize | |||||||
| BacoMind | |||||||
| Bacopa | |||||||
| Bergamot (Citrus bergamia) | |||||||
| Black Cohosh | |||||||
| Caffeine | |||||||
| Cannabidiol | |||||||
| Cannabinoids | |||||||
| Chamomile | |||||||
| Coffee | |||||||
| Curcumin | |||||||
| DHA | |||||||
| English Lavender | |||||||
| EPA (Eicosapentaenoic Acid) | |||||||
| Gotu Kola | |||||||
| Holy Basil | |||||||
| Kava kava | |||||||
| KSM-66 | |||||||
| Lavandula (unspecified) | |||||||
| lemon balm | |||||||
| lemon Verbena | |||||||
| Lithium | |||||||
| Magnesium | |||||||
| Magnesium Glycinate | |||||||
| Magnesium L-Threonate | |||||||
| Magnesium Oxide | |||||||
| Melatonin | |||||||
| Mint (unspecified) | |||||||
| Omega-3 | |||||||
| Passionflower | |||||||
| Phosphatidylserine | |||||||
| Pregnenolone | |||||||
| Saffron | |||||||
| Satiereal | |||||||
| Sensoril | |||||||
| Shoden | |||||||
| Synapsa | |||||||
| Tetrahydrocannabinol | |||||||
| Theanine | |||||||
| L-Tryptophan | |||||||
| Turmeric | |||||||
| Valerian | |||||||
| Vitamin B |
Selected evidence
5-HTP × Reduce anxiety symptoms
Unclear, 2 trials
- Trials
- 2
- Participants
- 30
- GRADE
- Low
Weighted-median standardized effect
0.06Source evidence
Selected evidence
affron × Reduce daily stress
Preliminary, 2 trials
- Trials
- 2
- Participants
- 103
- GRADE
- Low
Weighted-median standardized effect
0.20Source evidence
Selected evidence
affron × Reduce anxiety symptoms
Preliminary, 3 trials
- Trials
- 3
- Participants
- 191
- GRADE
- Low
Random-effects standardized effect
Source evidence
Selected evidence
affron × Lower stress load
Preliminary, 2 trials
- Trials
- 2
- Participants
- 19
- GRADE
- Low
Weighted-median standardized effect
0.30Source evidence
Selected evidence
Ashwagandha × Reduce daily stress
Preliminary, 14 trials
- Trials
- 14
- Participants
- 1,490
- GRADE
- Low
Random-effects standardized effect
Selected evidence
Ashwagandha × Reduce anxiety symptoms
Preliminary, 12 trials
- Trials
- 12
- Participants
- 1,364
- GRADE
- Low
Random-effects standardized effect
Selected evidence
Ashwagandha × Lower stress load
Preliminary, 13 trials
- Trials
- 13
- Participants
- 1,301
- GRADE
- Very low
Random-effects standardized effect
Selected evidence
Ashwagandha × Restore healthy cortisol rhythm
Unclear, 1 trial
- Trials
- 1
- Participants
- 50
- GRADE
- Very low
Weighted-median standardized effect
0.01Source evidence
Selected evidence
Bacognize × Reduce anxiety symptoms
Unclear, 1 trial
- Trials
- 1
- GRADE
- Moderate
Source evidence
Selected evidence
BacoMind × Reduce anxiety symptoms
Unclear, 1 trial
- Trials
- 1
- GRADE
- Moderate
Source evidence
Selected evidence
Bacopa × Reduce daily stress
Preliminary, 2 trials
- Trials
- 2
- Participants
- 46
- GRADE
- Low
Weighted-median standardized effect
1.51Source evidence
Selected evidence
Bacopa × Reduce anxiety symptoms
Unclear, 1 trial
- Trials
- 1
- GRADE
- Moderate
Source evidence
Selected evidence
Bergamot (Citrus bergamia) × Reduce daily stress
Likely helps, 1 trial
- Trials
- 1
- Participants
- 100
- GRADE
- Moderate
Weighted-median standardized effect
0.58Source evidence
Selected evidence
Bergamot (Citrus bergamia) × Reduce anxiety symptoms
Likely helps, 1 trial
- Trials
- 1
- Participants
- 100
- GRADE
- Moderate
Weighted-median standardized effect
0.51Source evidence
Selected evidence
Black Cohosh × Reduce anxiety symptoms
Preliminary, 3 trials
- Trials
- 3
- Participants
- 137
- GRADE
- Low
Weighted-median standardized effect
1.23Source evidence
Selected evidence
Caffeine × Reduce daily stress
Preliminary, 2 trials
- Trials
- 2
- Participants
- 48
- GRADE
- Low
Weighted-median standardized effect
-1.04Source evidence
Selected evidence
Caffeine × Reduce anxiety symptoms
Likely harm, 2 trials
- Trials
- 2
- Participants
- 626
- GRADE
- Moderate
Weighted-median standardized effect
-0.94Source evidence
Selected evidence
Cannabidiol × Reduce daily stress
Unclear, 2 trials
- Trials
- 2
- Participants
- 48
- GRADE
- Low
Weighted-median standardized effect
0.07Source evidence
Selected evidence
Cannabidiol × Reduce anxiety symptoms
Unclear, 4 trials
- Trials
- 4
- Participants
- 129
- GRADE
- Low
Random-effects standardized effect
Source evidence
Selected evidence
Cannabinoids × Reduce daily stress
Unclear, 1 trial
- Trials
- 1
- Participants
- 40
- GRADE
- Low
Weighted-median standardized effect
0.04Source evidence
Selected evidence
Cannabinoids × Reduce anxiety symptoms
Preliminary, 3 trials
- Trials
- 3
- Participants
- 1,142
- GRADE
- Very low
Random-effects standardized effect
Source evidence
Selected evidence
Cannabinoids × Lower day-to-day anxiety
Preliminary, 1 trial
- Trials
- 1
- Participants
- 40
- GRADE
- Low
Weighted-median standardized effect
0.40Source evidence
Selected evidence
Chamomile × Reduce anxiety symptoms
Unclear, 4 trials
- Trials
- 4
- Participants
- 207
- GRADE
- Low
Random-effects standardized effect
Source evidence
Selected evidence
Chamomile × Lower day-to-day anxiety
Preliminary, 1 trial
- Trials
- 1
- Participants
- 34
- GRADE
- Low
Weighted-median standardized effect
0.56Source evidence
Selected evidence
Coffee × Reduce anxiety symptoms
Likely helps, 1 trial
- Trials
- 1
- Participants
- 120
- GRADE
- Moderate
Weighted-median standardized effect
0.43Source evidence
Selected evidence
Curcumin × Reduce anxiety symptoms
Helps, 3 trials
- Trials
- 3
- Participants
- 1,298
- GRADE
- High
Random-effects standardized effect
Source evidence
Selected evidence
DHA × Reduce anxiety symptoms
Preliminary, 1 trial
- Trials
- 1
- Participants
- 18
- GRADE
- Low
Weighted-median standardized effect
1.05Source evidence
Selected evidence
English Lavender × Reduce daily stress
Preliminary, 2 trials
- Trials
- 2
- Participants
- 186
- GRADE
- Low
Weighted-median standardized effect
0.12Source evidence
Selected evidence
EPA (Eicosapentaenoic Acid) × Reduce anxiety symptoms
Preliminary, 1 trial
- Trials
- 1
- Participants
- 68
- GRADE
- Low
Weighted-median standardized effect
0.61Source evidence
Selected evidence
Gotu Kola × Feel calmer and more confident
Preliminary, 1 trial
- Trials
- 1
- Participants
- 14
- GRADE
- Low
Weighted-median standardized effect
0.61Source evidence
Selected evidence
Holy Basil × Reduce daily stress
Preliminary, 1 trial
- Trials
- 1
- Participants
- 85
- GRADE
- Low
Weighted-median standardized effect
0.13Source evidence
Selected evidence
Holy Basil × Reduce anxiety symptoms
Preliminary, 1 trial
- Trials
- 1
- Participants
- 150
- GRADE
- Low
Weighted-median standardized effect
4.00Source evidence
Selected evidence
Holy Basil × Lower stress load
Likely helps, 1 trial
- Trials
- 1
- Participants
- 136
- GRADE
- Moderate
Weighted-median standardized effect
0.75Source evidence
Selected evidence
Kava kava × Reduce anxiety symptoms
Helps, 2 trials
- Trials
- 2
- Participants
- 585
- GRADE
- High
Weighted-median standardized effect
0.10Source evidence
Selected evidence
KSM-66 × Reduce daily stress
Preliminary, 7 trials
- Trials
- 7
- Participants
- 351
- GRADE
- Very low
Random-effects standardized effect
Selected evidence
KSM-66 × Reduce anxiety symptoms
Likely helps, 7 trials
- Trials
- 7
- Participants
- 500
- GRADE
- Moderate
Random-effects standardized effect
Selected evidence
KSM-66 × Lower stress load
Likely helps, 6 trials
- Trials
- 6
- Participants
- 881
- GRADE
- Moderate
Random-effects standardized effect
Selected evidence
Lavandula (unspecified) × Reduce daily stress
Helps, 3 trials
- Trials
- 3
- Participants
- 757
- GRADE
- High
Weighted-median standardized effect
0.38Source evidence
Selected evidence
Lavandula (unspecified) × Reduce anxiety symptoms
Likely helps, 11 trials
- Trials
- 11
- Participants
- 11,216
- GRADE
- Moderate
Random-effects standardized effect
Selected evidence
Lavandula (unspecified) × Lower day-to-day anxiety
Likely helps, 1 trial
- Trials
- 1
- Participants
- 3,419
- GRADE
- Moderate
Weighted-median standardized effect
0.06Source evidence
Selected evidence
lemon balm × Reduce daily stress
Preliminary, 3 trials
- Trials
- 3
- Participants
- 100
- GRADE
- Low
Weighted-median standardized effect
1.57Source evidence
Selected evidence
lemon balm × Reduce anxiety symptoms
Preliminary, 3 trials
- Trials
- 3
- Participants
- 144
- GRADE
- Low
Weighted-median standardized effect
1.57Source evidence
Selected evidence
lemon balm × Lower stress load
Likely helps, 1 trial
- Trials
- 1
- GRADE
- Moderate
Source evidence
Selected evidence
lemon Verbena × Reduce daily stress
Unclear, 1 trial
- Trials
- 1
- Participants
- 71
- GRADE
- Very low
Weighted-median standardized effect
0.15Source evidence
Selected evidence
Lithium × Reduce anxiety symptoms
No clear effect, 3 trials
- Trials
- 3
- Participants
- 679
- GRADE
- High
Weighted-median standardized effect
0.00Source evidence
Selected evidence
Magnesium × Reduce daily stress
Likely no clear effect, 2 trials
- Trials
- 2
- Participants
- 229
- GRADE
- Moderate
Weighted-median standardized effect
0.00Source evidence
Selected evidence
Magnesium × Reduce anxiety symptoms
Unclear, 3 trials
- Trials
- 3
- Participants
- 153
- GRADE
- Low
Weighted-median standardized effect
0.07Source evidence
Selected evidence
Magnesium × Lower stress load
Preliminary, 1 trial
- Trials
- 1
- GRADE
- Low
Source evidence
Selected evidence
Magnesium Glycinate × Reduce daily stress
Likely helps, 1 trial
- Trials
- 1
- Participants
- 153
- GRADE
- Moderate
Weighted-median standardized effect
0.22Source evidence
Selected evidence
Magnesium Glycinate × Reduce anxiety symptoms
Likely no clear effect, 1 trial
- Trials
- 1
- Participants
- 153
- GRADE
- Moderate
Weighted-median standardized effect
0.00Source evidence
Selected evidence
Magnesium L-Threonate × Reduce anxiety symptoms
Likely no clear effect, 2 trials
- Trials
- 2
- GRADE
- Moderate
Source evidence
Selected evidence
Magnesium Oxide × Lower stress load
Preliminary, 1 trial
- Trials
- 1
- GRADE
- Low
Source evidence
Selected evidence
Melatonin × Reduce anxiety symptoms
Preliminary, 5 trials
- Trials
- 5
- Participants
- 335
- GRADE
- Low
Random-effects standardized effect
Selected evidence
Mint (unspecified) × Reduce anxiety symptoms
Likely no clear effect, 1 trial
- Trials
- 1
- Participants
- 3,419
- GRADE
- Moderate
Weighted-median standardized effect
0.03Source evidence
Selected evidence
Omega-3 × Reduce daily stress
Unclear, 2 trials
- Trials
- 2
- Participants
- 113
- GRADE
- Low
Weighted-median standardized effect
0.01Source evidence
Selected evidence
Omega-3 × Reduce anxiety symptoms
Preliminary, 5 trials
- Trials
- 5
- Participants
- 2,465
- GRADE
- Very low
Random-effects standardized effect
Selected evidence
Passionflower × Reduce daily stress
Likely helps, 1 trial
- Trials
- 1
- GRADE
- Moderate
Source evidence
Selected evidence
Passionflower × Lower stress load
Unclear, 1 trial
- Trials
- 1
- Participants
- 65
- GRADE
- Low
Weighted-median standardized effect
0.08Source evidence
Selected evidence
Phosphatidylserine × Reduce daily stress
Preliminary, 2 trials
- Trials
- 2
- Participants
- 20
- GRADE
- Low
Weighted-median standardized effect
0.40Source evidence
Selected evidence
Phosphatidylserine × Lower stress load
Preliminary, 5 trials
- Trials
- 5
- Participants
- 72
- GRADE
- Low
Random-effects standardized effect
Source evidence
Selected evidence
Pregnenolone × Reduce anxiety symptoms
Preliminary, 1 trial
- Trials
- 1
- Participants
- 31
- GRADE
- Low
Weighted-median standardized effect
0.50Source evidence
Selected evidence
Saffron × Reduce daily stress
Preliminary, 2 trials
- Trials
- 2
- Participants
- 103
- GRADE
- Low
Weighted-median standardized effect
0.20Source evidence
Selected evidence
Saffron × Reduce anxiety symptoms
Preliminary, 4 trials
- Trials
- 4
- Participants
- 278
- GRADE
- Low
Random-effects standardized effect
Source evidence
Selected evidence
Saffron × Lower stress load
Preliminary, 2 trials
- Trials
- 2
- Participants
- 19
- GRADE
- Low
Weighted-median standardized effect
0.23Source evidence
Selected evidence
Satiereal × Reduce daily stress
Unclear, 1 trial
- Trials
- 1
- GRADE
- Low
Source evidence
Selected evidence
Satiereal × Reduce anxiety symptoms
Preliminary, 3 trials
- Trials
- 3
- Participants
- 191
- GRADE
- Low
Random-effects standardized effect
Source evidence
Selected evidence
Satiereal × Lower stress load
Preliminary, 2 trials
- Trials
- 2
- Participants
- 19
- GRADE
- Low
Weighted-median standardized effect
0.30Source evidence
Selected evidence
Sensoril × Reduce daily stress
Likely helps, 4 trials
- Trials
- 4
- Participants
- 203
- GRADE
- Moderate
Weighted-median standardized effect
0.36Source evidence
Selected evidence
Sensoril × Reduce anxiety symptoms
Preliminary, 4 trials
- Trials
- 4
- Participants
- 332
- GRADE
- Low
Random-effects standardized effect
Source evidence
Selected evidence
Sensoril × Lower stress load
Likely helps, 3 trials
- Trials
- 3
- Participants
- 704
- GRADE
- Moderate
Weighted-median standardized effect
1.19Source evidence
Selected evidence
Shoden × Reduce daily stress
Preliminary, 4 trials
- Trials
- 4
- Participants
- 243
- GRADE
- Low
Random-effects standardized effect
Source evidence
Selected evidence
Shoden × Reduce anxiety symptoms
Likely helps, 5 trials
- Trials
- 5
- Participants
- 432
- GRADE
- Moderate
Random-effects standardized effect
Selected evidence
Shoden × Lower stress load
Likely helps, 5 trials
- Trials
- 5
- Participants
- 821
- GRADE
- Moderate
Random-effects standardized effect
Selected evidence
Synapsa × Reduce daily stress
Likely no clear effect, 1 trial
- Trials
- 1
- GRADE
- Moderate
Source evidence
Selected evidence
Synapsa × Reduce anxiety symptoms
Unclear, 1 trial
- Trials
- 1
- GRADE
- Moderate
Source evidence
Selected evidence
Tetrahydrocannabinol × Reduce anxiety symptoms
Unclear, 2 trials
- Trials
- 2
- Participants
- 41
- GRADE
- Low
Weighted-median standardized effect
0.00Source evidence
Selected evidence
Theanine × Reduce daily stress
Preliminary, 4 trials
- Trials
- 4
- Participants
- 113
- GRADE
- Low
Random-effects standardized effect
Source evidence
Selected evidence
Theanine × Reduce anxiety symptoms
Preliminary, 1 trial
- Trials
- 1
- Participants
- 18
- GRADE
- Low
Weighted-median standardized effect
0.22Source evidence
Selected evidence
Theanine × Lower day-to-day anxiety
Preliminary, 2 trials
- Trials
- 2
- Participants
- 84
- GRADE
- Low
Weighted-median standardized effect
0.52Source evidence
Selected evidence
L-Tryptophan × Reduce anxiety symptoms
Preliminary, 2 trials
- Trials
- 2
- Participants
- 36
- GRADE
- Low
Weighted-median standardized effect
0.66Source evidence
Selected evidence
Turmeric × Reduce anxiety symptoms
Helps, 3 trials
- Trials
- 3
- Participants
- 1,298
- GRADE
- High
Random-effects standardized effect
Source evidence
Selected evidence
Valerian × Reduce daily stress
Preliminary, 1 trial
- Trials
- 1
- Participants
- 37
- GRADE
- Low
Weighted-median standardized effect
1.69Source evidence
Selected evidence
Valerian × Reduce anxiety symptoms
Preliminary, 4 trials
- Trials
- 4
- Participants
- 176
- GRADE
- Low
Random-effects standardized effect
Source evidence
Selected evidence
Vitamin B × Reduce daily stress
Likely helps, 2 trials
- Trials
- 2
- Participants
- 317
- GRADE
- Moderate
Weighted-median standardized effect
0.09Source evidence
Selected evidence
Vitamin B × Reduce anxiety symptoms
No clear effect, 2 trials
- Trials
- 2
- Participants
- 670
- GRADE
- High
Weighted-median standardized effect
0.00Source evidence
Evidence map: Stress
Explore clinical evidence across the ways people experience stress, anxiety, and recovery.
Across 46 ingredients and 7 outcomes, this map shows 85 studied pairs covering 127 distinct clinical trials.
Where cells are blank, the (ingredient, outcome) pair has not been studied — 237 such gaps remain on this map.
Methodology
Each studied pair shows its V2 verdict, GRADE certainty, contributing-trial total, and source evidence. Where an audited standardized effect is available, the receipt shows the estimate and its confidence interval when available. Generated 2026-07-30 from 127 contributing trials.
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