Evidence map Updated Oct 24, 2026

Metabolic health

Explore clinical evidence across blood sugar, insulin response, blood lipids, and body weight.

135 ingredients · 7 outcomes · 382 trials

Evidence map

Evidence across metabolic health

Benefit Mixed / early No clear benefit Harm Not studied

Metabolic health evidence map Lower fasting blood sugar

Metabolic health Ingredient	Lower fasting blood sugar	Lower HbA1c	Better glycemic control score	Less insulin resistance	Lower fasting insulin	Lower triglycerides	Lower body weight
5-HTP
Acetyl L-Carnitine
Acetyl-L-Carnitine-L-Arginine
Affron
Aged Garlic Extract
Algal Oil (Schizochytrium)
Aloe
Alpha Lipoic Acid
Apple Cider Vinegar
Artichoke
Avocado
Barberry (Berberis spp.)
Barley
BCM-95
Bean
Benfotiamine
Berberine
Bergamot (Citrus bergamia)
Beta Glucans
Betaine
Betaine Anhydrous
Bitter Melon
Black Garlic
Black Seed
Blonde Psyllium
Blue Green Algae
Brewer's Yeast
Brown Seaweed and Kelp
Calcium pyruvate
Caloric Restriction
Capsaicin
Capsicum
Carnitine
Cassia
Chinese Yam
Chitosan
Chlorella
Chlorogenic Acid
Chlorophyll
Chokeberry
Chromium
Chromium Chloride
Chromium picolinate
Cinnamon
Clove
Coffee
Coleus
Conjugated Linoleic Acid
Cornelian Cherry
Crocin
Cumin
Curcumin
CurcuWIN
Cyanocobalamin
DASH Diet
Dogwood / Cornus
EGCG
EPA
Omega-3 Ethyl Esters (EPA + DHA)
Fennel
Fenugreek
Fenugreek Fiber
Fish Liver oil
Fish Oil
Flax
Flaxseed Fiber
Flaxseed Oil
Garcinia
Garlic
Ginsenosides
Glucomannan
Green Coffee
Green Tea
Guggul
Gymnema
Hibiscus
Hoodia
Hydroxycitric Acid
Inositol
Ketogenic Diet
Ketone
Krill Oil
Lecithin
Longvida
Loquat
Mangosteen
Mediterranean Diet
Meriva
Methylcobalamin
Milk Protein
Momordica
Monacolin
Moringa
Niacin (vitamin B3)
Olive
Olive Oil
Omega-3
Onion
Oriental Ginseng (Panax ginseng)
Pectin
Phyllanthus
Pinitol
Polyunsaturated fatty acid
Pomegranate
Potato
Pterostilbene
Pyruvate
Red Yeast Rice
Resistant Starch
Rice Bran
Rose Hip
Saffron
Sargassum
Satiereal
Sodium pyruvate
Soy
Soy Protein
Spirulina
Synephrine
Tauroursodeoxycholic Acid
Theracurmin
Tocotrienols
Trigonelline
Ursolic Acid
Vanadium
Vitamin B1
Vitamin B12
Whey Protein
White Kidney Bean
Yeast
Zinc
Zinc Acetate
Zinc Gluconate
Zinc Oxide
Zinc Picolinate

Evidence map: Metabolic health

Explore clinical evidence across blood sugar, insulin response, blood lipids, and body weight.

Across 135 ingredients and 7 outcomes, this map shows 270 studied pairs covering 382 distinct clinical trials.

Where cells are blank, the (ingredient, outcome) pair has not been studied — 675 such gaps remain on this map.

Methodology

Each studied pair shows its V2 verdict, GRADE certainty, contributing-trial total, and source evidence. Where an audited standardized effect is available, the receipt shows the estimate and its confidence interval when available. Generated 2026-10-24 from 382 contributing trials.

Metabolic health

Evidence across metabolic health

5-HTP × Lower body weight

Acetyl L-Carnitine × Lower body weight

Acetyl-L-Carnitine-L-Arginine × Lower body weight

Affron × Lower body weight

Aged Garlic Extract × Lower triglycerides

Algal Oil (Schizochytrium) × Lower triglycerides

Aloe × Lower fasting blood sugar

Alpha Lipoic Acid × Lower fasting blood sugar

Alpha Lipoic Acid × Lower HbA1c

Alpha Lipoic Acid × Less insulin resistance

Alpha Lipoic Acid × Lower body weight

Apple Cider Vinegar × Lower fasting blood sugar

Apple Cider Vinegar × Lower HbA1c

Apple Cider Vinegar × Less insulin resistance

Apple Cider Vinegar × Lower fasting insulin

Apple Cider Vinegar × Lower body weight

Artichoke × Lower triglycerides

Artichoke × Lower body weight

Avocado × Lower triglycerides

Avocado × Lower body weight

Barberry (Berberis spp.) × Lower fasting blood sugar

Barberry (Berberis spp.) × Lower HbA1c

Barberry (Berberis spp.) × Less insulin resistance

Barberry (Berberis spp.) × Lower fasting insulin

Barberry (Berberis spp.) × Lower triglycerides

Barberry (Berberis spp.) × Lower body weight

Barley × Lower triglycerides

BCM-95 × Lower fasting blood sugar

BCM-95 × Less insulin resistance

Bean × Lower fasting blood sugar

Bean × Lower HbA1c

Bean × Less insulin resistance

Benfotiamine × Lower HbA1c

Berberine × Lower fasting blood sugar

Berberine × Lower HbA1c

Berberine × Less insulin resistance

Berberine × Lower fasting insulin

Berberine × Lower triglycerides

Berberine × Lower body weight

Bergamot (Citrus bergamia) × Lower fasting blood sugar

Bergamot (Citrus bergamia) × Less insulin resistance

Bergamot (Citrus bergamia) × Lower triglycerides

Beta Glucans × Lower triglycerides

Betaine × Lower body weight

Betaine Anhydrous × Lower body weight

Bitter Melon × Lower fasting blood sugar

Bitter Melon × Lower HbA1c

Bitter Melon × Better glycemic control score

Bitter Melon × Lower triglycerides

Bitter Melon × Lower body weight

Black Garlic × Lower triglycerides

Black Seed × Lower fasting blood sugar

Black Seed × Lower HbA1c

Black Seed × Less insulin resistance

Black Seed × Lower triglycerides

Blonde Psyllium × Lower fasting blood sugar

Blonde Psyllium × Lower HbA1c

Blonde Psyllium × Less insulin resistance

Blonde Psyllium × Lower body weight

Blue Green Algae × Lower triglycerides

Brewer's Yeast × Lower fasting blood sugar

Brewer's Yeast × Lower HbA1c

Brewer's Yeast × Less insulin resistance

Brown Seaweed and Kelp × Lower body weight

Calcium pyruvate × Lower body weight

Caloric Restriction × Lower fasting blood sugar

Caloric Restriction × Lower HbA1c

Caloric Restriction × Less insulin resistance

Caloric Restriction × Lower triglycerides

Caloric Restriction × Lower body weight

Capsaicin × Lower body weight

Capsicum × Lower body weight

Carnitine × Lower body weight

Cassia × Lower fasting blood sugar

Cassia × Lower HbA1c

Chinese Yam × Lower fasting blood sugar

Chitosan × Lower triglycerides

Chitosan × Lower body weight