affron

Best for

Lift and steady your mood

Large effect, needs confirmation · 28–30 mg/day for 6–8 weeks · 2 studies , n=118

47 papers · 13 claims · 119 outcomes scored · 11 positive

Outcomes

What affron actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Lift and steady your mood Large effect, needs confirmation

Good days come more often and bad ones feel less heavy.

2 RCTs n=118 28–30 mg 6–8 wk #1/20

33598475·35813851

large

2 RCTs n=118

28–30 mg

6–8 wk

#1 /20

Stay asleep through the night Likely benefit

Fewer wake-ups and more unbroken hours of real rest.

3 meta-analyses n=353 0.6–300 mg 5–6 wk #2/15

36141931·33925432·35813851

moderate

3 meta-analyses n=353 Meta-analyzed

0.6–300 mg

5–6 wk

#2 /15

Reduce emotional overwhelm Promising early signal

The background noise of worry, irritability, and low mood gets quieter.

2 RCTs n=144 28 mg 6–12 wk #3/7

34463070·35813851

moderate

2 RCTs n=144

28 mg

6–12 wk

#3 /7

Lift mood and reduce negativity Promising early signal

Fewer dark stretches and more spontaneous positive moments through the day.

1 RCT n=82 28 mg 12 wk #2/6

34463070

moderate

1 RCT n=82

28 mg

12 wk

#2 /6

Lower day-to-day anxiety Faint early signal

The background hum of worry that colors everything gets quieter.

3 meta-analyses n=191 0.6–300 mg 1–5 wk #9/48

34745923·36141931·37288021

small

3 meta-analyses n=191 Meta-analyzed

0.6–300 mg

1–5 wk

#9 /48

Ease anxiety in older adults Faint early signal

Quiets the health worries and body tension that build with age.

3 meta-analyses n=191 0.6–300 mg 1–5 wk #9/45

34745923·36141931·37288021

small

3 meta-analyses n=191 Meta-analyzed

0.6–300 mg

1–5 wk

#9 /45

Reduce pre-competition anxiety Faint early signal

Quiets the overthinking that hijacks execution right before you compete.

3 meta-analyses n=191 0.6–300 mg 1–5 wk #9/45

34745923·36141931·37288021

small

3 meta-analyses n=191 Meta-analyzed

0.6–300 mg

1–5 wk

#9 /45

Reduce daily stress Faint early signal

Everyday pressure stops running your nervous system hot.

3 RCTs n=122 0.06–30 mg 4–8 wk

33598475·40698027·37447245

small

3 RCTs n=122

0.06–30 mg

4–8 wk

—

Ease depression symptoms Likely real but unnoticeable

Lowers the weight of sadness, low energy, and emotional numbness over weeks.

11 meta-analyses n=18k 0.6–300 mg 4–48 wk #2/41

22552758·23280545·24299602·29849461 +7 more

trivial

11 meta-analyses n=18k Meta-analyzed I²=94%

0.6–300 mg

4–48 wk

#2 /41

Ease winter depression symptoms Likely real but unnoticeable

Compensates for the sunlight deficit when days get short.

10 meta-analyses n=18k 15–125 mg 4–48 wk #2/39

22552758·23280545·24299602·29849461 +6 more

trivial

10 meta-analyses n=18k Meta-analyzed I²=94%

15–125 mg

4–48 wk

#2 /39

Ease depression tied to chronic pain Likely real but unnoticeable

When pain loosens its grip, mood follows.

10 meta-analyses n=18k 15–125 mg 4–48 wk #2/39

22552758·23280545·24299602·29849461 +6 more

trivial

10 meta-analyses n=18k Meta-analyzed I²=94%

15–125 mg

4–48 wk

#2 /39

Improve everyday quality of life Probably doesn't help

Fewer days where health problems dictate what you can and cannot do.

2 RCTs n=151 15.5–30 mg 4–6 wk

33925432·40698027

trivial

2 RCTs n=151

15.5–30 mg

4–6 wk

—

Reduce everyday pain intensity Not enough research

Lower intensity, fewer flares, and longer stretches of relief.

1 meta-analysis n=— 100 mg 12 wk #10/55

33322318

—

1 meta-analysis n=— Meta-analyzed

100 mg

12 wk

#10 /55

Outcome	Effect	Evidence	Dose	Weeks	Rank
Lift and steady your mood Large effect, needs confirmation	large	2 RCTs n=118	28–30 mg	6–8 wk	#1/20
Stay asleep through the night Likely benefit	moderate	3 meta-analyses n=353 Meta-analyzed	0.6–300 mg	5–6 wk	#2/15
Reduce emotional overwhelm Promising early signal	moderate	2 RCTs n=144	28 mg	6–12 wk	#3/7
Lift mood and reduce negativity Promising early signal	moderate	1 RCT n=82	28 mg	12 wk	#2/6
Lower day-to-day anxiety Faint early signal	small	3 meta-analyses n=191 Meta-analyzed	0.6–300 mg	1–5 wk	#9/48
Ease anxiety in older adults Faint early signal	small	3 meta-analyses n=191 Meta-analyzed	0.6–300 mg	1–5 wk	#9/45
Reduce pre-competition anxiety Faint early signal	small	3 meta-analyses n=191 Meta-analyzed	0.6–300 mg	1–5 wk	#9/45
Reduce daily stress Faint early signal	small	3 RCTs n=122	0.06–30 mg	4–8 wk	—
Ease depression symptoms Likely real but unnoticeable	trivial	11 meta-analyses n=18k Meta-analyzed	0.6–300 mg	4–48 wk	#2/41
Ease winter depression symptoms Likely real but unnoticeable	trivial	10 meta-analyses n=18k Meta-analyzed	15–125 mg	4–48 wk	#2/39
Ease depression tied to chronic pain Likely real but unnoticeable	trivial	10 meta-analyses n=18k Meta-analyzed	15–125 mg	4–48 wk	#2/39
Improve everyday quality of life Probably doesn't help	trivial	2 RCTs n=151	15.5–30 mg	4–6 wk	—
Reduce everyday pain intensity Not enough research		1 meta-analysis n=— Meta-analyzed	100 mg	12 wk	#10/55

Buy well

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Chosen for adequate affron dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

angina severe

COVID-19 severe

diverticulitis severe

headache mild

nausea mild

decreased appetite mild

increased appetite mild

sedation mild

Sources

Generated August 14, 2026

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