Articles & Research

Support cholinergic signaling and phospholipid/synapse building to aid memory, focus, and cognitive resilience.

• •The duo is a plausible dual-pathway stack (choline + uridine) with animal and mechanistic support
• •Direct Alpha GPC + UMP human data are lacking, so synergy is theoretical, not proven.

Stress resilience with steady daytime energy and calmer sleep

Dual-core, theoretical synergy: good rationale, solid solo data, but no head-to-head Ashwagandha+Rhodiola trials yet.

Sharper memory encoding plus steadier attention/mental clarity by boosting acetylcholine from two angles and supporting neuron membranes while dialing down stress reactivity.

• •Dual-core, theoretical synergy: both work on their own
• •Together looks additive with plausible complementarity, but no direct human A+B head-to-head proof yet.

Calm, focused alertness for short-term cognitive tasks while reducing caffeine's jitters and blood-pressure reactivity.

• •Real but modest, short-term benefits with a "gas pedal + steering" effect
• •Best for focused tasks, not all-day stimulation.

Support memory, learning, and long-term brain plasticity (neurogenesis/BDNF) while easing stress-related interference with recall.

The combo is a theoretical dual-pathway stack (neurotrophic + cholinergic), but there are no direct head-to-head studies proving synergy.

Night-time recovery and sleep support in active people, with possible benefits for stress/PMS when magnesium is paired with vitamin B6.

• •Magnesium + B6 shows small, condition-specific synergy
• •Adding zinc hasn't proven extra benefits and can compete with magnesium at high doses.

Reduce inflammation and oxidative stress while protecting fragile omega-3 fats from oxidation to support vascular and metabolic health.

• •Protective + dual-pathway combo with promising but not definitive synergy
• •Best for lowering inflammation/oxidative stress markers, not proven to outperform omega-3 alone on hard outcomes.

Reduce upper-airway allergy symptoms and swelling (sneezing, runny nose, sinus pressure) and provide adjunct immune support during respiratory infections.

• •Theory-supported, partially studied combo
• •Helpful for some, but true "A+B>C than A or B alone" synergy is unproven.

Help vitamin A do its jobs (vision, skin and mucous barrier, and immune signaling) by making sure the body can move, convert, and use vitamin A properly—especially when zinc is low. In deficient settings, the duo has reduced persistent diarrhea and improved night vision more than either alone.

Context-dependent synergy: proven in deficiency settings (especially for persistent diarrhea and pregnancy night blindness), but additive or null elsewhere.