Quercetin

Quercetin

Best for

Catch fewer colds and infections

Likely strong benefit · 250 mg/day for 12 weeks · 1 study , n=120

40 papers · 8 claims · 108 outcomes scored · 5 positive

Outcomes

What quercetin actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Catch fewer colds and infections Likely strong benefit
large
1 RCT n=120 250 mg 12 wk #3/17
Improve insulin sensitivity Large effect, needs confirmation
large
2 RCTs n=106 1000 mg 1–12 wk
Steady your blood sugar levels Large effect, needs confirmation
large
2 RCTs n=82 400–1000 mg 10–12 wk
Flatten post-meal blood sugar spikes Promising early signal
moderate
1 RCT n=24 1000 mg 1 wk
Lower your blood pressure Proven modest benefit
small
6 meta-analyses n=759 Meta-analyzed 100–1000 mg 6–10 wk #3/81
Lower bad and total cholesterol Not enough research
2 RCTs n=— 150–400 mg 6–10 wk
Lower triglycerides Not enough research
1 RCT n=— 400 mg 10 wk
Raise good cholesterol levels May have slight negative effect
small
2 RCTs n=278 150–400 mg 6–10 wk

Risk profile

Adverse events and known drug interactions

Safety events

treatment-related_carcinogenic_lesions (kidney, urinary bladder, intestine) in male rats severe
anaphylaxis severe
pneumonia severe
gastroenteritis severe
urinary_tract_infection severe
pro-oxidant effects in glutathione-depleted states; metabolic interactions affecting estrogen metabolism moderate
No serious adverse events reported in included RCTs; minor side-effects (headache, nausea, tingling) noted in other long-term reports mild
gastro-oesophageal reflux disease mild

Drug interactions

Tacrolimus major increases concentration
Carbamazepine major increases concentration
Antidepressants major increases concentration
Antipsychotics major increases concentration
Selexipag major increases concentration
Diclofenac major increases concentration
Warfarin major increases concentration
Quetiapine major increases concentration
Tucatinib major increases concentration
Cyclosporine moderate increases concentration

Sources

  1. 1. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. (2009)
  2. 2. Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers. (2011)
  3. 3. Does Quercetin Improve Cardiovascular Risk factors and Inflammatory Biomarkers in Women with Type 2 Diabetes: A Double-blind Randomized Controlled Clinical Trial. (2013)
  4. 4. The effect of quercetin on plasma oxidative status, C-reactive protein and blood pressure in women with rheumatoid arthritis. (2014)
  5. 5. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (2016)
  6. 6. Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovary Syndrome Patients: A Randomized Placebo-Controlled Double-Blind Clinical Trial. (2018)
  7. 7. Quercetin exhibits multi-target anti-allergic effects in animal models: a systematic review and meta-analysis of preclinical studies. (2025)
  8. 8. Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study. (2022)
  9. 9. Promising Effects of 3-Month Period of Quercetin Phytosome® Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study. (2022)
  10. 10. Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial. (2015)

Generated August 14, 2026

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