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Articles & Research

Alpha GPC + Uridine: Can This Duo Build Better Synapses?
Synergy Dual Core

Alpha GPC + Uridine: Can This Duo Build Better Synapses?

Alpha GPC + Uridine Monophosphate

Support cholinergic signaling and phospholipid/synapse building to aid memory, focus, and cognitive resilience.
  • •The duo is a plausible dual-pathway stack (choline + uridine) with animal and mechanistic support
  • •Direct Alpha GPC + UMP human data are lacking, so synergy is theoretical, not proven.
Essential Core:
Alpha GPC Uridine Monophosphate
promising evidence•moderate confidence
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Ashwagandha + Rhodiola: Calm Energy or Just Hype?
Synergy Dual Core

Ashwagandha + Rhodiola: Calm Energy or Just Hype?

Ashwagandha + Rhodiola

Stress resilience with steady daytime energy and calmer sleep
Dual-core, theoretical synergy: good rationale, solid solo data, but no head-to-head Ashwagandha+Rhodiola trials yet.
Essential Core:
Ashwagandha Rhodiola
emerging evidence•moderate confidence
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Brain Fuel That Slows Cognitive Decline
Synergy Dual Core

Brain Fuel That Slows Cognitive Decline

Vitamin B Complex + Omega-3

Support brain aging and cognitive function by lowering homocysteine (via B vitamins) and enriching/repairing brain cell membranes and calming inflammation (via omega-3), with suggestive human data that the two work better when both statuses are adequate.
Essential Core:
Vitamin B Complex (with sensible B6, adequate folate and B12) Omega-3 (EPA+DHA)
promising evidence•moderate confidence
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Memory Stack With Real Clinical Data
Synergy Dual Core

Memory Stack With Real Clinical Data

Bacopa Monnieri + Citicoline

Sharper memory encoding plus steadier attention/mental clarity by boosting acetylcholine from two angles and supporting neuron membranes while dialing down stress reactivity.
  • •Dual-core, theoretical synergy: both work on their own
  • •Together looks additive with plausible complementarity, but no direct human A+B head-to-head proof yet.
Essential Core:
Bacopa Monnieri Citicoline
emerging evidence•moderate confidence
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Heart Energy Amplified: Cellular Power Duo
Synergy Theoretical

Heart Energy Amplified: Cellular Power Duo

CoQ10 + Fish Oil

  • •Heart and vascular support by pairing mitochondrial energy/antioxidant support (CoQ10) with lipid/inflammation support (EPA/DHA from fish oil)
  • •Possible absorption help for CoQ10 when taken with fats.
Essential Core:
CoQ10 Fish Oil
promising evidence•moderate confidence
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Power + Endurance: The Proven Combo
Synergy Dual Core

Power + Endurance: The Proven Combo

Creatine + Beta-Alanine

Improve high-intensity exercise performance (repeated sprints, intervals lasting ~30 s to 4 min), training volume, and possibly body composition when combined with structured training. [1][2][3]
  • •Additive dual-pathway benefits for intense, repeated efforts
  • •No proven absorption synergy or extra boost for 1-rep max. [1][2]
Essential Core:
Creatine Beta-Alanine
promising evidence•moderate confidence
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2000% Absorption Boost: The Bioavailability Hack
Synergy Dual Core

2000% Absorption Boost: The Bioavailability Hack

Curcumin + Piperine

Boost curcumin's absorption and staying power in the body so its anti-inflammatory actions translate into real-world benefits (e.g., joint comfort, metabolic and liver markers). [1][2][9]
Proven absorption synergy (big) + plausible anti-inflammatory teamwork (early), but head-to-head clinical superiority over curcumin alone is not yet proven. [1][2][3][4][9][10][11]
Essential Core:
Curcumin Piperine
robust evidence•high confidence
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Calm Focus Unlocked: Kill The Jitters
Synergy Dual Core

Calm Focus Unlocked: Kill The Jitters

L-Theanine + Caffeine

Calm, focused alertness for short-term cognitive tasks while reducing caffeine's jitters and blood-pressure reactivity.
  • •Real but modest, short-term benefits with a "gas pedal + steering" effect
  • •Best for focused tasks, not all-day stimulation.
Essential Core:
Caffeine L-Theanine
promising evidence•moderate confidence
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Lion's Mane + Bacopa: Smart Memory Duo or Just Hype?
Synergy Theoretical

Lion's Mane + Bacopa: Smart Memory Duo or Just Hype?

Lion's Mane + Bacopa

Support memory, learning, and long-term brain plasticity (neurogenesis/BDNF) while easing stress-related interference with recall.
The combo is a theoretical dual-pathway stack (neurotrophic + cholinergic), but there are no direct head-to-head studies proving synergy.
Essential Core:
Bacopa
preliminary evidence•moderate confidence
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