Melatonin

Melatonin

Best for

Increase deep, restorative sleep

Large effect, needs confirmation · 0.3–9 mg/day for 4–12 weeks · 2 studies , n=24

101 papers · 10 claims · 203 outcomes scored · 9 positive

Evidence summary

Evidence summary

Proven benefit

Melatonin provides proven benefit for falling asleep faster and easing jet lag in adults with sleep-timing problems, while benefits are smaller for total sleep time and nighttime awakenings.

  • Across 28 studies (n=3,962), melatonin shortened time to fall asleep.2
  • Melatonin evidence spans 101 papers and 203 outcomes, strongest for sleep timing and jet lag.
  • Benefits are smaller for total sleep time and inconsistent for nighttime awakenings.2

Outcomes

What melatonin actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Increase deep, restorative sleep Large effect, needs confirmation

More time in the sleep stages where your body does its heaviest repair.

2 RCTs n=24 0.3–9 mg 4–12 wk #4/6
Fall asleep faster Proven benefit

Shrinks the gap between hitting the pillow and actually sleeping.

28 meta-analyses n=4.0k 0.15–12 mg 0–52 wk #1/19
Stay asleep through the night Studies contradict

Fewer wake-ups and more unbroken hours of real rest.

18 meta-analyses n=2.0k 0.3–24 mg 4–52 wk #8/15
Recover from jet lag faster Likely benefit

Gets your internal clock back on local time so you lose fewer days.

9 meta-analyses n=1.1k 0.3–8 mg 0–6 wk #1/2
Break the insomnia cycle Promising early signal

Quiets the nervous-system overdrive that keeps you wired at bedtime.

6 RCTs n=364 0.5–20 mg 2–17 wk #2/14
Improve overall sleep quality Proven modest benefit

Deeper, less interrupted nights that leave you recharged by morning.

29 meta-analyses n=6.1k 0.5–50 mg 1–104 wk #2/37
Sleep longer each night Likely modest benefit

More genuine sleep hours so your body finishes its repair cycles.

25 meta-analyses n=3.8k 0.3–24 mg 0–52 wk #2/12
Wake up clear-headed Likely modest benefit

Less grogginess, more energy from the moment you open your eyes.

19 meta-analyses n=1.4k 0.3–50 mg 0–17 wk #1/14
Stay alert on long drives Barely detectable

Sharper reaction times and steadier steering when driving fatigue sets in.

5 meta-analyses n=440 0.5–10 mg 4–17 wk #2/4
Spend more time in REM sleep Not enough research

More time in the sleep stage that processes emotions and consolidates memory.

2 meta-analyses n=139 2–10 mg 4–10 wk

Forms & standardisation

Most human trials use oral melatonin in straightforward tablets, capsules, or prolonged-release tablets—not flashy multi-ingredient sleep blends.23 If your goal is falling asleep faster, a simple immediate-release product fits melatonin's job as a fast "night has started" signal; prolonged-release versions aim to mimic the body's slower overnight drip.12 Pick a label that clearly lists the exact milligrams per serving so you can actually match a studied dose.

Risk profile

Adverse events and known drug interactions

Safety events

fatigue severe
insomnia severe
major side effects (severe dizziness, vivid nightmares, crippling drowsiness, severe headache, behavioral changes, pain worsening) severe
major side effects (combination arm: severe dizziness, vivid nightmares, drowsiness, severe headache, behavioral changes, pain worsening) severe
drowsiness severe
nausea severe
stroke (acute ischemic event) severe
severe sedation / somnolence severe

Drug interactions

other moderate decreases effect
Lipid Modifying Agents moderate increases effect
Metformin moderate increases effect
Blood Glucose Lowering moderate increases effect
Antineoplastic Agents moderate increases effect
Hypnotics And Sedatives moderate additive
other moderate increases concentration
Antithrombotic Agents moderate increases toxicity
Antihypertensives moderate decreases effect
Antithrombotic Agents moderate increases toxicity

Frequently asked

Common questions

How much melatonin should you take for sleep?

Most positive sleep studies land somewhere between 0.5 and 5 mg nightly, even though the full research range runs much wider.2 Bigger doses show up in papers, but the evidence doesn't tell a simple "more is better" story.12

Does melatonin actually work for jet lag?

Yes—jet lag is one of melatonin's clearest use cases. Reviews show it helps your body clock line up with local time faster when you take it around the new bedtime after crossing time zones.13

Why does melatonin help me fall asleep but not keep me asleep?

That pattern fits the data. Melatonin's main job is sending a "night has started" signal to your body clock, so studies more consistently improve sleep onset than overnight wake-ups.12

How long before bed should you take melatonin?

Think in terms of the bedtime you want to hit, not the middle of the night after you've already been awake for hours. Trials usually line melatonin up with the target sleep window or the destination bedtime in jet lag because it shifts timing more than it acts like an instant sedative.123

Can you take melatonin every night?

Many studies use melatonin nightly for days to weeks, and some continue much longer.2 It makes the most sense when you use it to solve an actual timing problem—like trouble falling asleep at the right time or travel-related clock mismatch.12

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