Glutathione
Best for
Build glutathione antioxidant levels
Likely benefit · 300–1260 mg/day for 3–26 weeks · 4 studies , n=232
8 papers · 2 claims · 30 outcomes scored · 2 positive
Outcomes
What glutathione actually does, by outcome
Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.
Your cells' main internal antioxidant defense gets deeper reserves.
Your immune system dials back its attack on the gut lining.
| Outcome | Effect | Evidence | Dose | Weeks | Rank |
|---|---|---|---|---|---|
| Build glutathione antioxidant levels Likely benefit | | 4 RCTs n=232 | 300–1260 mg | 3–26 wk | #1/13 |
| Reduce inflammatory bowel flare-ups Not enough research | | 1 RCT n=55 | 65 mg/kg/day | 24 wk | #5/8 |
Recommended Glutathione products
Real products that dose Glutathione where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.
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Nootropics Depot
Reduced Glutathione
Well dosed 1,000 mg/day A formulaBrand audit 87/100
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Designs for Health
Glutathione Power
Well dosed 1 Gram(s)/day A formulaBrand audit 80/100
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Pure Encapsulations
Liposomal Glutathione
Well dosed 750 mg/day A formulaBrand audit 78/100
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Swanson
L-Glutathione 500 mg
Well dosed 500 mg/day A formulaBrand audit 69/100
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SuperSmart
Reduced Glutathione 1000 mg
Well dosed 1,000 mg/day A formulaBrand audit 63/100
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Thorne
Glutathione-SR
Well dosed 525 mg/day B formulaBrand audit 79/100
Chosen for adequate Glutathione dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.
Risk profile
Adverse events and known drug interactions
Drug interactions
Sources
- 1. A clinical trial of glutathione supplementation in autism spectrum disorders. (2011) ↑
- 2. Impact of Glutathione and Vitamin B-6 in Cirrhosis Patients: A Randomized Controlled Trial and Follow-Up Study. (2020) ↑
- 3. Effects of Oral Liposomal Glutathione in Altering the Immune Responses Against Mycobacterium tuberculosis and the Mycobacterium bovis BCG Strain in Individuals With Type 2 Diabetes. (2021) ↑
- 4. Randomized Clinical Trial of How Long-Term Glutathione Supplementation Offers Protection from Oxidative Damage and Improves HbA1c in Elderly Type 2 Diabetic Patients. (2022) ↑
- 5. Oral Glutathione and Growth in Cystic Fibrosis: A Multicenter, Randomized, Placebo-controlled, Double-blind Trial. (2020) ↑
- 6. Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis. (2015) ↑
- 7. The Effects of Oral Liposomal Glutathione and In Vitro Everolimus in Altering the Immune Responses against Mycobacterium bovis BCG Strain in Individuals with Type 2 Diabetes. (2021) ↑
- 8. Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study. (2015) ↑
Generated August 14, 2026
Related
More evidence for Glutathione
Evidence guide
L-Glutathione
NewThe Body's Emergency Responder: How L-Glutathione Stepped From a 1921 Lab Bench Into Modern Self-Care
Evidence guide
Mar 27, 2026
Ingredient evidence
Ingredient evidence
NewGlutamine
All scored outcomes
Aug 14, 2026
Ingredient evidence
Ingredient evidence
NewProbiotics
All scored outcomes
Aug 14, 2026