Riboflavin

Best for

Get fewer headaches and migraines

Large effect, needs confirmation · 200 mg/day for 12 weeks · 1 study , n=60

6 papers · 5 claims · 17 outcomes scored · 4 positive

Outcomes

What riboflavin actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Get fewer headaches and migraines Large effect, needs confirmation

Cuts the number of attacks per month so headache days stop piling up.

1 RCT n=60 200 mg 12 wk #1/9

29629048

large

1 RCT n=60

200 mg

12 wk

#1 /9

Reduce migraine disruption Large effect, needs confirmation

Headaches steal fewer workdays, social plans, and hours of patience.

1 RCT n=60 200 mg 12 wk #2/12

29629048

large

1 RCT n=60

200 mg

12 wk

#2 /12

Shorten migraine attacks Large effect, needs confirmation

Each episode wraps up sooner so you recover your day faster.

2 meta-analyses n=60 200 mg 12 wk #1/6

29629048·39388181

large

2 meta-analyses n=60 Meta-analyzed

200 mg

12 wk

#1 /6

Ease headache and migraine pain Not enough research

Dials down how intense each headache feels when it hits.

1 RCT n=60 200 mg 12 wk #4/14

29629048

trivial

1 RCT n=60

200 mg

12 wk

#4 /14

Ease nausea during migraines Not enough research

Less stomach-churning so attacks are easier to ride out.

1 meta-analysis n=— — —

39388181

—

1 meta-analysis n=— Meta-analyzed

—

Outcome	Effect	Evidence	Dose	Weeks	Rank
Get fewer headaches and migraines Large effect, needs confirmation	large	1 RCT n=60	200 mg	12 wk	#1/9
Reduce migraine disruption Large effect, needs confirmation	large	1 RCT n=60	200 mg	12 wk	#2/12
Shorten migraine attacks Large effect, needs confirmation	large	2 meta-analyses n=60 Meta-analyzed	200 mg	12 wk	#1/6
Ease headache and migraine pain Not enough research	trivial	1 RCT n=60	200 mg	12 wk	#4/14
Ease nausea during migraines Not enough research		1 meta-analysis n=— Meta-analyzed	—	—	—

Risk profile

Adverse events and known drug interactions

Safety events

vomiting/emesis

urine discoloration (yellow urine)

treatment-emergent adverse events (overall)

Gastrointestinal disorders

Infections and infestations

General disorders and administration site conditions

Respiratory, thoracic and mediastinal disorders

Nervous system disorders

Drug interactions

Chlorpromazine moderate decreases concentration

Imipramine moderate decreases concentration

Amitriptyline moderate decreases concentration

Co-studied with

Supplements that share evidence with riboflavin

Sources

Generated August 14, 2026

Riboflavin

What riboflavin actually does, by outcome

Adverse events and known drug interactions

Supplements that share evidence with riboflavin

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