Siliphos
Best for
Lower elevated liver enzymes
Large effect, needs confirmation · 80–700 mg/day for 4–49 weeks · 3 studies , n=202
6 papers · 2 claims · 12 outcomes scored · 2 positive
Outcomes
What siliphos actually does, by outcome
Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.
Outcome Effect size Evidence Dose Weeks Rank
Lower elevated liver enzymes Large effect, needs confirmation
Brings down blood markers that spike when liver cells are damaged.
3 RCTs n=202 80–700 mg 4–49 wk #9/41
3 RCTs
n=202
80–700 mg
4–49 wk
#9 /41
Reverse fatty liver buildup Not enough research
Shrinks fat deposits in the liver and calms the inflammation driving disease forward.
1 RCT n=51 700 mg 49 wk #9/17
1 RCT
n=51
700 mg
49 wk
#9 /17
| Outcome | Effect | Evidence | Dose | Weeks | Rank |
|---|---|---|---|---|---|
| Lower elevated liver enzymes Large effect, needs confirmation | | 3 RCTs n=202 | 80–700 mg | 4–49 wk | #9/41 |
| Reverse fatty liver buildup Not enough research | | 1 RCT n=51 | 700 mg | 49 wk | #9/17 |
Sources
- 1. A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). (2010) ↑
- 2. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. (2012) ↑
- 3. Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial. (2019) ↑
- 4. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. (2007) ↑
- 5. Milk Thistle Treatment for Children and Adults with Trichotillomania: A Double-Blind, Placebo-Controlled, Crossover Negative Study. (2019) ↑
- 6. Silybum marianum Extract: A Highly Effective Natural Alternative to Retinoids to Prevent Skin Aging Without Side Effects. (2025) ↑
Generated August 14, 2026