Diindolylmethane

Best for

Improve ovulation and fertility hormones

Large effect, needs confirmation · 150 mg/day for 52 weeks · 1 study , n=97

2 papers · 2 claims · 10 outcomes scored · 2 positive

Outcomes

What diindolylmethane actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Improve ovulation and fertility hormones Large effect, needs confirmation

Strengthens the estrogen and progesterone signals that drive ovulation.

1 RCT n=97 150 mg 52 wk #4/10

28560655

large

1 RCT n=97

150 mg

52 wk

#4 /10

Shift estrogen metabolism toward safer paths Promising early signal

Tilts how your body breaks estrogen down toward the gentler metabolites and away from the harsher ones.

1 RCT n=98 150 mg 52 wk

28560655

moderate

1 RCT n=98

150 mg

52 wk

—

Outcome	Effect	Evidence	Dose	Weeks	Rank
Improve ovulation and fertility hormones Large effect, needs confirmation	large	1 RCT n=97	150 mg	52 wk	#4/10
Shift estrogen metabolism toward safer paths Promising early signal	moderate	1 RCT n=98	150 mg	52 wk	—

Risk profile

Adverse events and known drug interactions

Safety events

tumor promotion (colon and liver) in animal studies; potential carcinogenesis concerns severe

Myocardial hypoxia on ECG moderate

Acute respiratory viral infection moderate

Abundant flocculent discharge from the genital tract moderate

nausea mild

headache mild

vomiting mild

flatulence mild

Drug interactions

other moderate unknown

Cyclosporine moderate decreases concentration

Indinavir moderate decreases concentration

Tacrolimus moderate decreases concentration

Verapamil moderate decreases concentration

Fexofenadine moderate decreases concentration

Warfarin moderate decreases concentration

Paclitaxel moderate increases effect

Gemcitabine moderate increases effect

Erlotinib moderate increases effect

Sources

Generated August 14, 2026

Diindolylmethane

What diindolylmethane actually does, by outcome

Adverse events and known drug interactions

More evidence for Diindolylmethane

DIM at the Crossroads: How a Broccoli Molecule Became a Clue in Hormone Health

DHEA

Red Clover

Diindolylmethane

More evidence for Diindolylmethane

NewDIM at the Crossroads: How a Broccoli Molecule Became a Clue in Hormone Health

NewDHEA

NewRed Clover

DIM at the Crossroads: How a Broccoli Molecule Became a Clue in Hormone Health

DHEA

Red Clover