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Licorice

Licorice

Best for

Ease indigestion and heartburn

Likely benefit · 75–150 mg/day for 4–4 weeks · 1 meta-analysis , n=300

19 papers · 2 claims · 62 outcomes scored · 2 positive

Outcomes

What licorice actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Ease indigestion and heartburn Likely benefit
moderate 		3 meta-analyses n=300 Meta-analyzed 75–150 mg 4–4 wk #2/11
Stabilize electrolytes in kidney disease Promising early signal
moderate 		2 RCTs n=14 300–750 mg 3–8 wk #2/3
Buy well

Recommended Licorice products

Real products that dose Licorice where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Licorice dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

hypokalaemia life_threatening
ventricular arrhythmia life_threatening

Drug interactions

Drug:Warfarin major increases effect
Digoxin major increases toxicity
Antithrombotic Agents moderate increases toxicity

Sources

  1. 1. An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. (2012) ↑
  2. 2. Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial. (2025) ↑
  3. 3. Non-Chinese herbal medicines for functional dyspepsia. (2023) ↑
  4. 4. A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers of health and adiposity. (2011) ↑
  5. 5. Effect of licorice on patients with HSD11B1 gene polymorphisms- a pilot study. (2021) ↑
  6. 6. Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial. (2018) ↑
  7. 7. Randomized placebo-controlled clinical study on enhancement of Medha (intelligence quotient) in school going children with Yahstimadhu granules. (2015) ↑
  8. 8. Daily liquorice consumption for two weeks increases augmentation index and central systolic and diastolic blood pressure. (2014) ↑
  9. 9. The Effect of Dried Glycyrrhiza Glabra L. Extract on Obesity Management with Regard to PPAR-γ2 (Pro12Ala) Gene Polymorphism in Obese Subjects Following an Energy Restricted Diet. (2017) ↑
  10. 10. Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial. (2024) ↑

Generated August 14, 2026

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