Pregnenolone
Evidence status
Limited evidence to recommend for any consumer outcome yet.
5 papers · 0 claims · 19 outcomes scored
Risk profile
Adverse events and known drug interactions
Safety events
nausea
abdominal pain
headache
irritability
diarrhoea
constipation
facial tic
Drug interactions
Digoxin major decreases concentration
Sources
- 1. Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits. (2013) ↑
- 2. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. (2022) ↑
- 3. Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder. (2023) ↑
- 4. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment-seeking individuals with alcohol use disorder. (2025) ↑
- 5. Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial. (2020) ↑
Generated August 14, 2026