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Saccharomyces boullardii

Saccharomyces boullardii

Best for

Reduce diarrhea and recover faster

Likely strong benefit for 1 weeks · 1 meta-analysis , n=927

5 papers · 2 claims · 5 outcomes scored · 2 positive

Outcomes

What saccharomyces boullardii actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Prevent diarrhea from antibiotics Likely strong benefit
large 		1 meta-analysis n=8.0k Meta-analyzed — — #3/5
Reduce diarrhea and recover faster Likely strong benefit
large 		2 meta-analyses n=927 Meta-analyzed — 1 wk #3/17

Risk profile

Adverse events and known drug interactions

Safety events

nausea mild
skin rash mild
taste disturbance
diarrhea
headache
epigastric pain
urticaria
gastrointestinal disturbance (composite: diarrhea, epigastric pain, nausea)

Drug interactions

Amoxicillin minor increases effect
Vonoprazan minor increases effect
Amoxicillin minor unknown

Sources

  1. 1. Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations. (2007) ↑
  2. 2. Probiotics are effective at preventing Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. (2016) ↑
  3. 3. Strain-specific and outcome-specific efficacy of probiotics for the treatment of irritable bowel syndrome: A systematic review and meta-analysis. (2021) ↑
  4. 4. Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy. (2020) ↑

Generated August 14, 2026

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