Browse all articles

Home Get the app
Ursolic Acid

Ursolic Acid

Best for

Boost skin hydration

Large effect, needs confirmation for 4 weeks · 1 study , n=40

4 papers · 3 claims · 15 outcomes scored · 1 positive

Outcomes

What ursolic acid actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Boost skin hydration Large effect, needs confirmation
large 		1 RCT n=40 2.5 other 4 wk #9/13
Reduce fine lines and wrinkles Not enough research
2 RCTs n=— 2.5 other 4 wk —
Lose body fat Not enough research
1 study n=— 450 mg 8 wk —

Risk profile

Adverse events and known drug interactions

Safety events

gamma-glutamyl transferase increased moderate
alanine aminotransferase increased moderate
microscopic hematuria mild
proteinuria mild
fever mild
abdominal distention mild
aspartate aminotransferase increased mild
triglycerides increased mild

Drug interactions

Verapamil moderate increases effect
Cyclosporine moderate increases effect
Doxorubicin moderate decreases effect
Epirubicin moderate increases effect
Insulin moderate additive
Sorafenib moderate increases effect

Sources

  1. 1. Ursolic Acid-induced elevation of serum irisin augments muscle strength during resistance training in men. (2014) ↑
  2. 2. Annurca Apple Oleolite as Functional Ingredient for the Formulation of Cosmetics with Skin-Antiaging Activity. (2024) ↑
  3. 3. Apple oil as a source of ursolic acid for the treatment of hyperpigmentary disorders with molecular and clinical evaluation. (2025) ↑
  4. 4. Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study. (2017) ↑

Generated August 14, 2026

Related

More evidence for Ursolic Acid

Want personalized recommendations?

Show me what works for me