Bile Acid

Best for

Lower elevated total bile acids

Faint early signal for 2 weeks · 1 meta-analysis , n=1.3k

17 papers · 1 claim · 37 outcomes scored · 1 positive

Outcomes

What bile acid actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Lower elevated total bile acids Faint early signal

Brings the total amount of bile acid circulating in your blood back into a healthier range.

2 meta-analyses n=1.3k 1000–2000 other 2 wk

22695903·36719881

small

2 meta-analyses n=1.3k Meta-analyzed I²=93%

1000–2000 other

2 wk

—

Outcome	Effect	Evidence	Dose	Weeks	Rank
Lower elevated total bile acids Faint early signal	small	2 meta-analyses n=1.3k Meta-analyzed	1000–2000 other	2 wk	—

Sources

1. Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. (2012) ↑
2. Efficacy and safety of ursodeoxycholic acid in children with cholestasis: A systematic review and meta-analysis. (2023) ↑
3. Efficacy and Safety of "URSA Complex" in Subjects with Physical Fatigue: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial. (2016) ↑
4. Ursodeoxycholic Acid Use After Bariatric Surgery: Effects on Metabolic and Inflammatory Blood Markers. (2023) ↑
5. Ursodeoxycholic acid for primary biliary cirrhosis. (2012) ↑
6. Oral solubilized ursodeoxycholic acid therapy in amyotrophic lateral sclerosis: a randomized cross-over trial. (2012) ↑
7. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. (2021) ↑
8. Role of ursodeoxycholic acid in neonatal indirect hyperbilirubinemia: a systematic review and meta-analysis of randomized controlled trials. (2022) ↑
9. Evaluation of therapeutic effect of oral Ursodeoxycholic Acid on indirect hyperbilirubinemia in term neonates undergoing phototherapy: A randomized controlled clinical trial. (2023) ↑
10. The effects of ursodeoxycholic acid on cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials. (2025) ↑

Generated August 14, 2026