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Capsaicinoids

Capsaicinoids

Best for

Feel full longer and crave less

Promising early signal · 100–200 mg/day for 4 weeks · 1 study , n=63

7 papers · 3 claims · 18 outcomes scored · 3 positive

Outcomes

What capsaicinoids actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Feel full longer and crave less Promising early signal
moderate 		1 RCT n=63 100–200 mg 4 wk #9/28
Burn more fat for fuel Likely modest benefit
small 		6 meta-analyses n=198 Meta-analyzed 2–200 mg 4 wk #3/18
Boost your resting metabolic rate Faint early signal
small 		3 meta-analyses n=63 Meta-analyzed 2–200 mg 4 wk #1/5

Risk profile

Adverse events and known drug interactions

Safety events

adverse events / symptoms (assessed by symptom questionnaire)
dyspepsia
bowel irregularities
diarrhea
sprained ankle
elevated blood pressure
stomach ache
increased urination

Sources

  1. 1. Effect of capsinoids on energy metabolism in human subjects. (2010) ↑
  2. 2. Dihydrocapsiate does not increase energy expenditure nor fat oxidation during aerobic exercise in men with overweight/obesity: a randomized, triple-blinded, placebo-controlled, crossover trial. (2022) ↑
  3. 3. Effects of phenylcapsaicin on aerobic capacity and physiological parameters in active young males: a randomized, triple-blinded, placebo-controlled, crossover trial. (2023) ↑
  4. 4. A natural sustained-intestinal release formulation of red chili pepper extracted capsaicinoids (Capsifen®) safely modulates energy balance and endurance performance: a randomized, double-blind, placebo-controlled study. (2024) ↑
  5. 5. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. (2012) ↑
  6. 6. Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study. (2010) ↑
  7. 7. Effects of different phenylcapsaicin doses on resistance training performance, muscle damage, protein breakdown, metabolic response, ratings of perceived exertion, and recovery: a randomized, triple-blinded, placebo-controlled, crossover trial. (2023) ↑

Generated August 14, 2026

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