icariin
Evidence status
Limited evidence to recommend for any consumer outcome yet.
13 papers · 0 claims · 41 outcomes scored
Risk profile
Adverse events and known drug interactions
Safety events
hepatocellular vacuolization severe
hepatocyte necrosis severe
elevated serum creatinine moderate
developmental toxicity (reduced body length, delayed yolk sac absorption, morphological abnormalities such as pericardial edema, crooked body, tail malformation, spinal deformity) moderate
hepatocellular degeneration moderate
Drug interactions
Amoxicillin-Clavulanate moderate increases effect
Ampicillin moderate increases effect
Vancomycin moderate decreases effect
Sources
- 1. Icariin inhibits hyperglycemia-induced cell death in penile cavernous tissue and improves erectile function in type 1 diabetic rats. (2025) ↑
- 2. Effect of icariin on fracture healing in an ovariectomized rat model of osteoporosis. (2017) ↑
- 3. Icariin Attenuates M1 Activation of Microglia and Aβ Plaque Accumulation in the Hippocampus and Prefrontal Cortex by Up-Regulating PPARγ in Restraint/Isolation-Stressed APP/PS1 Mice. (2019) ↑
- 4. Icariin Inhibits Pulmonary Hypertension Induced by Monocrotaline through Enhancement of NO/cGMP Signaling Pathway in Rats. (2016) ↑
- 5. Antiosteoporotic effect of icariin in ovariectomized rats is mediated via the Wnt/β-catenin pathway. (2016) ↑
- 6. Icariin accelerates bone regeneration by inducing osteogenesis-angiogenesis coupling in rats with type 1 diabetes mellitus. (2024) ↑
- 7. Icariin decreases the expression of APP and BACE-1 and reduces the β-amyloid burden in an APP transgenic mouse model of Alzheimer's disease. (2014) ↑
- 8. Icariin ameliorates oxidative stress-induced inflammation, apoptosis, and heart failure in isoproterenol-challenged Wistar rats. (2023) ↑
- 9. Exploration of the protective mechanisms of Icariin against cisplatin-induced renal cell damage in canines. (2024) ↑
- 10. The Effects of Treatment with Icariin on Immune Tolerance in the Recurrent Spontaneous Abortion Mice. (2023) ↑
Generated August 14, 2026
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