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Vinpocetine

Vinpocetine

Best for

Slow cognitive decline in dementia

Likely real but unnoticeable · 10–40 mg/day · 1 meta-analysis , n=837

4 papers · 3 claims · 11 outcomes scored · 1 positive

Outcomes

What vinpocetine actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Slow cognitive decline in dementia Likely real but unnoticeable
trivial 		1 meta-analysis n=837 Meta-analyzed 10–40 mg — #5/23
Boost overall cognitive performance Not enough research
1 meta-analysis n=— Meta-analyzed 30–60 mg — —
Increase blood flow to the brain Not enough research
1 meta-analysis n=— Meta-analyzed 10–30 mg — —
Buy well

Recommended Vinpocetine products

Real products that dose Vinpocetine where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Vinpocetine dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

fetal death severe
post-implantation loss severe
abortion severe
ventricular septum defect severe
decreased fetal weight moderate
supernumerary ribs moderate
delayed ossification moderate
abnormal vaginal discharge moderate

Drug interactions

Digoxin major increases concentration
Indinavir major increases concentration
Warfarin major additive
Tolbutamide moderate increases concentration
Omeprazole minor unknown
Dextromethorphan minor unknown
Chlorzoxazone minor unknown

Sources

  1. 1. Safety and Efficacy of Vinpocetine as a Neuroprotective Agent in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis. (2022) ↑
  2. 2. Vinpocetine for cognitive impairment and dementia. (2003) ↑
  3. 3. Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders, a randomized controlled clinical study. (2014) ↑
  4. 4. Comparative efficacy of neuroprotective agents for improving neurological function and prognosis in acute ischemic stroke: a network meta-analysis. (2024) ↑

Generated August 14, 2026

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