Chastetree / Vitex agnus-castus

Best for

Improve overall sexual function

Faint early signal · 3.2–4.8 mg/day for 4–16 weeks · 2 studies , n=157

4 papers · 4 claims · 16 outcomes scored · 4 positive

Outcomes

What chastetree / vitex agnus-castus actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Improve overall sexual function Faint early signal

Every phase improves: desire, arousal, comfort, and orgasm.

2 RCTs n=157 3.2–4.8 mg 4–16 wk #1/7

34667794·37849864

small

2 RCTs n=157

3.2–4.8 mg

4–16 wk

#1 /7

Ease behavior changes before periods Likely real but unnoticeable

Reduces irritability, emotional reactivity, and restlessness before your period.

1 RCT n=170 20–40 mg 8–12 wk #4/9

11159568

trivial

1 RCT n=170

20–40 mg

8–12 wk

#4 /9

Ease premenstrual disruption Likely real but unnoticeable

Premenstrual symptoms interfere less with daily activities and relationships.

1 RCT n=170 20–40 mg 8–12 wk #4/9

11159568

trivial

1 RCT n=170

20–40 mg

8–12 wk

#4 /9

Ease premenstrual symptoms Likely real but unnoticeable

Less cramping, bloating, mood dips, and disruption before your period.

1 RCT n=170 20–40 mg 8–12 wk #4/9

11159568

trivial

1 RCT n=170

20–40 mg

8–12 wk

#4 /9

Outcome	Effect	Evidence	Dose	Weeks	Rank
Improve overall sexual function Faint early signal	small	2 RCTs n=157	3.2–4.8 mg	4–16 wk	#1/7
Ease behavior changes before periods Likely real but unnoticeable	trivial	1 RCT n=170	20–40 mg	8–12 wk	#4/9
Ease premenstrual disruption Likely real but unnoticeable	trivial	1 RCT n=170	20–40 mg	8–12 wk	#4/9
Ease premenstrual symptoms Likely real but unnoticeable	trivial	1 RCT n=170	20–40 mg	8–12 wk	#4/9

Buy well

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Real products that dose Chastetree / Vitex agnus-castus where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Chastetree / Vitex agnus-castus dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

Acne mild

Multiple abscesses mild

Intermenstrual bleeding mild

Urticaria mild

Early menstrual period mild

Gastric upset mild

nausea mild

spotting mild

Drug interactions

Pramipexole moderate additive

Sources

Generated August 14, 2026

Chastetree / Vitex agnus-castus

What chastetree / vitex agnus-castus actually does, by outcome

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Adverse events and known drug interactions

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