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Diamine Oxidase

Diamine Oxidase

Evidence status

Limited evidence to recommend for any consumer outcome yet.

2 papers · 2 claims · 16 outcomes scored

Outcomes

What diamine oxidase actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Calm chronic hives outbreaks Not enough research
1 RCT n=— 12.6 mg 8 wk —
Reduce bloating and trapped gas Not enough research
1 RCT n=— 12.6 mg 8 wk —

Risk profile

Adverse events and known drug interactions

Safety events

headache
gastrointestinal complaints

Drug interactions

Diminazene Aceturate major decreases effect
Citalopram major decreases effect
Diphenhydramine moderate unknown
Ranitidine moderate unknown
Cimetidine moderate unknown
Hydroxyzine moderate unknown
Chlorpheniramine moderate unknown
Naproxen moderate decreases effect
Heparin minor decreases effect
Ibuprofen minor unknown

Sources

  1. 1. Exogenous Supplementation with DAO Enzyme in Women with Fibromyalgia: A Double-Blind Placebo-Controlled Clinical Trial. (2023) ↑
  2. 2. Effect of diamine oxidase (DAO) enzyme dietary supplementation in subjects with insomnia symptoms and single nucleotide polymorphisms of the AOC1 gene: a randomized double-blind placebo-controlled study. (2026) ↑

Generated August 14, 2026

Related

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