Fatty acids

Best for

Lower triglycerides

Large effect, needs confirmation · 10–180 mL/day for 8–52 weeks · 1 study , n=42

5 papers · 3 claims · 13 outcomes scored · 3 positive

Outcomes

What fatty acids actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Lower triglycerides Large effect, needs confirmation

Reduces the blood fats that rise after meals and drive heart risk.

1 RCT n=42 10–180 mL 8–52 wk

39885430

large

1 RCT n=42

10–180 mL

8–52 wk

—

Improve omega-3 to omega-6 ratio Likely modest benefit

Less raw material for inflammation, more for resolving it.

1 RCT n=211 50–80 g 16 wk #2/6

33978160

small

1 RCT n=211

50–80 g

16 wk

#2 /6

Lower bad and total cholesterol Faint early signal

Cuts the cholesterol that builds into artery plaque over time.

1 RCT n=42 10–180 mg 8–52 wk

39885430

small

1 RCT n=42

10–180 mg

8–52 wk

—

Outcome	Effect	Evidence	Dose	Weeks	Rank
Lower triglycerides Large effect, needs confirmation	large	1 RCT n=42	10–180 mL	8–52 wk	—
Improve omega-3 to omega-6 ratio Likely modest benefit	small	1 RCT n=211	50–80 g	16 wk	#2/6
Lower bad and total cholesterol Faint early signal	small	1 RCT n=42	10–180 mg	8–52 wk	—

Risk profile

Adverse events and known drug interactions

Safety events

single_case_hepatotoxicity severe

gastrointestinal disturbance (nausea, dyspepsia, fishy taste/odor)

Sources

Generated August 14, 2026

Fatty acids

What fatty acids actually does, by outcome

Adverse events and known drug interactions

More evidence for Fatty acids

Metabolic health: evidence map across 82 supplements

Omega-6 Fatty Acids

Black Garlic

Flax

Flaxseed Oil

Garlic

Fatty acids

More evidence for Fatty acids

NewMetabolic health: evidence map across 82 supplements

NewOmega-6 Fatty Acids

NewBlack Garlic

NewFlax

NewFlaxseed Oil

NewGarlic

Metabolic health: evidence map across 82 supplements

Omega-6 Fatty Acids

Black Garlic

Flax

Flaxseed Oil

Garlic