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Luteolin

Luteolin

What the trials found

Luteolin has no established human benefit across health outcomes because evidence remains limited to a short preclinical study rather than controlled human trials.

Median effective dose, most-studied outcomes

  • Support lower whole-body inflammation 55 mg/kg 3 wk
Full protocol, 2 outcomes

Risk, worst reported severity

  • hepatic steatosis
  • no overt toxicity reported
  • atorvastatin major
  • ceftiofur major
All 13 events and interactions
Protocol

Dose, timing & forms

How much

There is no established human luteolin dose. The only reviewed study tested 10 to 100 mg/kg in animals over roughly 3.2 weeks, with a significant result for whole-body inflammation markers at some doses.1 Do not treat those animal doses as a conversion chart for capsules or as proof that a higher dose works better in people.

When and how long

No human trial protocol establishes whether luteolin works best in the morning, evening, with meals, or away from food. The reviewed research was short-term animal work, so a daily timing routine for people would be guesswork rather than evidence-based guidance.1 If you are considering a supplement, ask a clinician or pharmacist about timing around your medications.

Forms & standardisation

No specific luteolin extract, absorption-enhanced form, or label standardization has human outcome evidence in the reviewed material.1 Look for a label that clearly states the amount of luteolin per serving, but do not assume that a higher labeled amount creates a proven benefit. Luteolin is also naturally present in plant foods, although food content varies widely.2

Studied range, by outcome

Outcome Studied range Median effective Duration Evidence
Reduce oxidative stress 10–100 mg/kg — 3 wk 1 paper
Support lower whole-body inflammation 10–100 mg/kg 55 mg/kg 3 wk 1 paper 1 sig. endpoint

Adverse events and drug interactions

Safety events

hepatic steatosis
no overt toxicity reported
genotoxicity

Drug interactions

atorvastatin major increases concentration
ceftiofur major increases concentration
gefitinib moderate additive
erythromycin moderate increases effect
roxithromycin moderate increases effect
acetylspiramycin moderate increases effect
tylosin moderate increases effect
azithromycin moderate increases effect
tilmicosin moderate increases effect
mianserin moderate increases concentration
In context

What this is and how it works

  • One preclinical paper examined inflammation and oxidative-stress outcomes, but no human effect size or MCID is established.1
  • One paper reviewed here spans 15 outcomes, with evidence limited to animal research rather than human supplementation.

Luteolin is a flavonoid, a natural plant pigment found in foods such as celery, parsley, thyme, and some peppers.2 Supplements isolate it into capsules or powders, which is very different from getting small amounts through a varied diet.

Researchers are exploring whether luteolin changes the cell signals that tell the immune system to turn its inflammatory response up or down. Think of it as testing a hand on the immune system's volume knob, not proving that it fixes the cause of a person's symptoms.1 The reviewed experiment tracked inflammation and oxidative-stress markers in animals, but it does not establish a working mechanism or benefit in people.1

Bottom line

Luteolin is an interesting food-derived compound, but it is not yet a well-supported supplement choice for a specific health goal. The reviewed evidence is one short animal study, so people seeking reliable human benefits or a proven dose should wait for better trials.1 Anyone using prescription medicines should check with a pharmacist or clinician before trying it.

Frequently asked

Common questions

What is luteolin used for?

Luteolin is a plant compound sold in some supplements for inflammation-related goals. The reviewed evidence includes one short animal experiment, not human trials that establish a consumer benefit.1

Does luteolin reduce inflammation?

The single reviewed animal study found lower whole-body inflammation markers at some tested doses. That result does not show that luteolin lowers inflammation or improves symptoms in people.1

What is the best luteolin dose?

There is no evidence-based human luteolin dose from the reviewed research. The reported 10 to 100 mg/kg range comes from an animal experiment and should not be converted into a personal supplement dose.1

Is luteolin the same as quercetin?

No. Both are naturally occurring flavonoids, but they are distinct compounds with different chemical structures and research records.2

Sources

Sources

  1. 1. Luteolin preclinical evidence record: inflammation and oxidative stress outcomes
  2. 2. Luteolin, PubChem Compound Summary

Generated August 27, 2026

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