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Palmitoylethanolamide

Palmitoylethanolamide

Best for

Ease cold and flu severity

Large effect, needs confirmation · 350–600 mg/day for 2–12 weeks · 2 studies , n=82

18 papers · 4 claims · 65 outcomes scored · 3 positive

Outcomes

What palmitoylethanolamide actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Ease cold and flu severity Large effect, needs confirmation
large 		2 RCTs n=82 350–600 mg 2–12 wk #2/17
Reduce everyday pain intensity Likely benefit
moderate 		4 meta-analyses n=1.4k Meta-analyzed 300–1800 mg 4–12 wk #4/55
Reduce underlying allergy reactivity Likely benefit
moderate 		1 RCT n=108 350 mg 2 wk #1/5
Ease allergy symptoms Not enough research
1 RCT n=— 350 mg 2 wk —
Buy well

Recommended Palmitoylethanolamide products

Real products that dose Palmitoylethanolamide where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Palmitoylethanolamide dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

fatigue (severe episode) severe
palpitations moderate
urticaria moderate
drowsiness mild
gastrointestinal discomfort / diarrhea (sublingual formulation, sorbitol-associated) mild
diarrhea mild
dyspepsia mild
nausea mild

Drug interactions

Morphine moderate increases effect
Acetaminophen moderate increases effect
Tramadol moderate increases effect
Oxycodone moderate increases effect
Paclitaxel moderate decreases effect
Interferon Beta moderate increases effect
Citalopram minor additive
Levodopa minor additive

Co-studied with

Supplements that share evidence with palmitoylethanolamide

Sources

  1. 1. The Effect of Levagen+ (Palmitoylethanolamide) Supplementation on Symptoms of Allergic Rhinitis-A Double-Blind Placebo-Controlled Trial. (2023) ↑
  2. 2. Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. (2023) ↑
  3. 3. The Efficacy of Palmitoylethanolamide (Levagen+) on the Incidence and Symptoms of Upper Respiratory Tract Infection-A Double Blind, Randomised, Placebo-Controlled Trial. (2023) ↑
  4. 4. Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants-A Double-Blind Randomised Controlled Study. (2024) ↑
  5. 5. The Comparative Efficacy of Palmitoylethanolamide (PEA) With the Combination of Pregabalin and Nortriptyline on Post-extraction Trigeminal Neuropathy by Using Magnetic Resonance (MR) Neurography: A Randomized Clinical Trial. (2024) ↑
  6. 6. Extended Treatment with Micron-Size Oral Palmitoylethanolamide (PEA) in Chronic Pain: A Systematic Review and Meta-Analysis. (2024) ↑
  7. 7. Randomized split-mouth study on postoperative effects of palmitoylethanolamide for impacted lower third molar surgery. (2011) ↑
  8. 8. The effects of formulated palmitoylethanolamide supplementation on indicators of stress and heart rate variability in female university students: a randomised cross-over trial. (2025) ↑
  9. 9. Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial. (2024) ↑
  10. 10. The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial. (2024) ↑

Generated August 14, 2026

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