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Bromelain

Bromelain

Best for

Reduce pain and daily disability

Likely strong benefit · 1 meta-analysis , n=312

10 papers · 3 claims · 14 outcomes scored · 3 positive

Outcomes

What bromelain actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Reduce pain and daily disability Likely strong benefit
large 		1 meta-analysis n=312 Meta-analyzed — — #1/5
Reduce pain after surgery Large effect, needs confirmation
large 		2 RCTs n=82 200–300 mg 1–1 wk #1/3
Reduce everyday pain intensity Likely real but unnoticeable
trivial 		7 meta-analyses n=508 Meta-analyzed 100–800 mg 1–2 wk #8/55
Buy well

Recommended Bromelain products

Real products that dose Bromelain where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Bromelain dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

transient gastrointestinal upset mild

Co-studied with

Supplements that share evidence with bromelain

Sources

  1. 1. Ananas comosus Effect on Perineal Pain and Wound Healing After Episiotomy: A Randomized Double-Blind Placebo-Controlled Clinical Trial. (2016) ↑
  2. 2. Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars. (2016) ↑
  3. 3. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. (2004) ↑
  4. 4. Prospective double-blind clinical trial evaluating the effectiveness of Bromelain in the third molar extraction postoperative period. (2014) ↑
  5. 5. Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials. (2019) ↑
  6. 6. Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial. (2018) ↑
  7. 7. Bromelain-Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study. (2025) ↑
  8. 8. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study. (2024) ↑
  9. 9. The effect of bromelain in periodontal surgery: a double-blind randomized placebo-controlled trial. (2023) ↑
  10. 10. Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study. (2025) ↑

Generated August 14, 2026

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