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Maritime pine / Pycnogenol

Maritime pine / Pycnogenol

Evidence status

Limited evidence to recommend for any consumer outcome yet.

8 papers · 0 claims · 29 outcomes scored

Risk profile

Adverse events and known drug interactions

Safety events

rhabdomyolysis severe
flatulence mild
diarrhea mild
neck stiffness mild
adverse effects (various)
No acute toxicity (no mortality, no clinical signs)
Increased mean corpuscular hemoglobin (MCH)
Increased serum calcium

Drug interactions

Antithrombotic Agents moderate increases effect
Antihypertensives moderate increases effect

Co-studied with

Supplements that share evidence with maritime pine / pycnogenol

Sources

  1. 1. Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin. (2012) ↑
  2. 2. Pine bark (Pinus spp.) extract for treating chronic disorders. (2020) ↑
  3. 3. The effect of antioxidant supplementation on fatigue during exercise: potential role for NAD+(H). (2010) ↑
  4. 4. Cellular pharmacodynamic effects of Pycnogenol® in patients with severe osteoarthritis: a randomized controlled pilot study. (2017) ↑
  5. 5. A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Curcumin (Curcuma longa), Boswellia (Boswellia serrata), and French Maritime Pine Bark (Pinus pinaster). (2021) ↑
  6. 6. Herbal interventions for chronic asthma in adults and children: a systematic review and meta-analysis. (2010) ↑
  7. 7. A Systematic Review and Meta-analysis on the Effect of Herbal Medicine to Manage Sleep Dysfunction in Peri- and Postmenopause. (2018) ↑

Generated August 14, 2026

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