Diosmin
Best for
Protect the gut during radiation
Likely strong benefit · 1500–3000 mg/day for 1 weeks · 1 meta-analysis , n=228
4 papers · 3 claims · 8 outcomes scored · 3 positive
Outcomes
What diosmin actually does, by outcome
Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.
Reduces bowel injury, bleeding, and discomfort from pelvic radiation.
Keeps ankles and calves from puffing up on long flights or drives.
| Outcome | Effect | Evidence | Dose | Weeks | Rank |
|---|---|---|---|---|---|
| Protect the gut during radiation Likely strong benefit | | 1 meta-analysis n=228 Meta-analyzed | 1500–3000 mg | 1 wk | — |
| Reduce leg swelling during travel Promising early signal | | 2 RCTs n=132 | 450–1000 mg | 8–26 wk | #1/2 |
| Ease heavy, swollen legs Promising early signal | | 2 RCTs n=132 | 450–1000 mg | 8–26 wk | #1/2 |
Recommended Diosmin products
Real products that dose Diosmin where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.
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XYMOGEN
DioVasc
Well dosed 1,000 mg/day B formulaBrand audit 80/100
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XYMOGEN
Dio Vasc
Well dosed 1,000 mg/day C formulaBrand audit 80/100
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SuperSmart
Hemo Comfort
Well dosed 900 mg/day A formulaBrand audit 63/100
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Swanson
Diosmin & Hesperidin
Well dosed 1,000 mg/day C formulaBrand audit 69/100
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Doctor's Best
Vein Support
Well dosed 900 mg/day C formulaBrand audit 82/100
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We Like Vitamins
Diosmin Hesperidin 1000 mg
Well dosed 1,000 mg/day B formula
Chosen for adequate Diosmin dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.
Risk profile
Adverse events and known drug interactions
Safety events
Drug interactions
Co-studied with
Supplements that share evidence with diosmin
- Drug:Rivaroxaban 3 shared outcomes · d=1.08
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Same 3 shared outcomes · d=1.08
Sources
- 1. Use of Micronized Purified Flavonoid Fraction Together with Rivaroxaban Improves Clinical and Ultrasound Outcomes in Femoropopliteal Venous Thrombosis: Results of a Pilot Clinical Trial. (2019) ↑
- 2. Efficacy of a Low-Dose Diosmin Therapy on Improving Symptoms and Quality of Life in Patients with Chronic Venous Disease: Randomized, Double-Blind, Placebo-Controlled Trial. (2021) ↑
- 3. Micronized Purified Flavonoid Fraction in Hemorrhoid Disease: A Systematic Review and Meta-Analysis. (2020) ↑
- 4. A nutraceutical intervention for alleviating tired and heavy legs in healthy subjects: a randomized, double-blind, controlled study. (2025) ↑
Generated August 14, 2026
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