SAM-e
Evidence status
Limited evidence to recommend for any consumer outcome yet.
3 papers · 0 claims · 16 outcomes scored
Risk profile
Adverse events and known drug interactions
Safety events
esophageal_perforation severe
weight increased severe
nausea mild
gastrointestinal symptoms (nausea, upset stomach, diarrhoea) mild
headache mild
tiredness/fatigue mild
gastrointestinal complaints (nausea, transient GI symptoms) mild
skin irritation mild
Drug interactions
Warfarin moderate decreases effect
Daunorubicin moderate increases concentration
Co-studied with
Supplements that share evidence with sam-e
- Royaljelly 14 shared outcomes · d=0.46
-
Coq10 14 shared outcomes · d=0.46 - Drug:Donepezil 7 shared outcomes · d=0.99
-
Vitaminc 1 shared outcome · d=0.00 -
Vitamine 1 shared outcome · d=0.00 -
Mineral 1 shared outcome · d=0.00
Sources
- 1. A Phase II Randomized, Controlled Trial of S-Adenosylmethionine in Reducing Serum α-Fetoprotein in Patients with Hepatitis C Cirrhosis and Elevated AFP. (2015) ↑
- 2. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial. (2011) ↑
- 3. S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis. (2015) ↑
Generated August 14, 2026
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Ranking
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