Gotu Kola
Best for
Strengthen calm under pressure
Promising early signal · 750 mg/day for 8 weeks · 1 meta-analysis , n=14
9 papers · 3 claims · 28 outcomes scored · 3 positive
Outcomes
What gotu kola actually does, by outcome
Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.
Outcome Effect size Evidence Dose Weeks Rank
Strengthen calm under pressure Promising early signal
Fewer racing thoughts before decisions, steadier reactions when things go wrong.
1 meta-analysis n=14 750 mg 8 wk
1 meta-analysis
n=14
Meta-analyzed
750 mg
8 wk
—
Boost overall cognitive performance Likely modest benefit
Broad gains in memory, speed, and mental sharpness at once.
1 meta-analysis n=153 — — #2/21
1 meta-analysis
n=153
Meta-analyzed
I²=88%
—
—
#2 /21
Sharpen focus and mental stamina Likely modest benefit
Concentrate longer, resist distraction, and stay mentally sharp through demanding tasks.
1 meta-analysis n=146 20 g 13 wk #4/40
1 meta-analysis
n=146
Meta-analyzed
I²=77%
20 g
13 wk
#4 /40
| Outcome | Effect | Evidence | Dose | Weeks | Rank |
|---|---|---|---|---|---|
| Strengthen calm under pressure Promising early signal | | 1 meta-analysis n=14 Meta-analyzed | 750 mg | 8 wk | — |
| Boost overall cognitive performance Likely modest benefit | | 1 meta-analysis n=153 Meta-analyzed | — | — | #2/21 |
| Sharpen focus and mental stamina Likely modest benefit | | 1 meta-analysis n=146 Meta-analyzed | 20 g | 13 wk | #4/40 |
Risk profile
Adverse events and known drug interactions
Safety events
nausea severe
stomach pain mild
hepatocellular necrosis mild
lymphocytic infiltration mild
renal tubular necrosis mild
hydronephrosis mild
gastrointestinal discomfort mild
flatulence mild
Drug interactions
Digoxin moderate decreases effect
Risperidone moderate decreases effect
Valproic Acid moderate decreases effect
Fluorouracil moderate decreases concentration
Doxorubicin moderate increases effect
Sources
- 1. Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: A Systematic Review and Meta-analysis. (2017) ↑
- 2. Oral and Topical Centella asiatica in Type 2 Diabetes Mellitus Patients with Dry Skin: A Three-Arm Prospective Randomized Double-Blind Controlled Trial. (2020) ↑
- 3. Centella asiatica Improves Physical Performance and Health-Related Quality of Life in Healthy Elderly Volunteer. (2011) ↑
- 4. Efficacy and safety of Centella asiatica (L.) Urb. [Apiaceae] as a dietary supplement for glycemic control and lipid regulation in patients with type 2 diabetes: a randomized controlled trial in Thailand. (2025) ↑
- 5. Efficacy of Centella asiatica on mitigating temporomandibular pain and improving functionality: a randomized, double blind, pilot clinical trial. (2025) ↑
- 6. A Systematic Review of the Efficacy of Centella asiatica for Improvement of the Signs and Symptoms of Chronic Venous Insufficiency. (2013) ↑
- 7. Effects of Long-Term Supplementation with Centella asiatica (L.) Urb. Extract (CA-HE50) on Macular Pigment Optical Density: A Randomized, Double-Blind, Placebo-Controlled Trial. (2026) ↑
- 8. Centella asiatica triterpenes for diabetic neuropathy: a randomized, double-blind, placebo-controlled, pilot clinical study. (2018) ↑
- 9. A Prospective Randomized, Controlled, Double-Blind Trial of the Efficacy Using Centella Cream for Scar Improvement. (2018) ↑
Generated August 14, 2026