Nicotinamide Mononucleotide
Best for
Raise cellular NAD+ levels
Large effect, needs confirmation · 250–3000 mg/day for 2–20 weeks · 11 studies , n=239
19 papers · 2 claims · 58 outcomes scored · 1 positive
Outcomes
What nicotinamide mononucleotide actually does, by outcome
Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.
Replenish the coenzyme that powers hundreds of metabolic reactions.
Your body's internal age trends younger than the calendar predicts.
| Outcome | Effect | Evidence | Dose | Weeks | Rank |
|---|---|---|---|---|---|
| Raise cellular NAD+ levels Large effect, needs confirmation | | 11 RCTs n=239 | 250–3000 mg | 2–20 wk | #1/2 |
| Slow biological aging markers Not enough research | | 1 RCT n=34 | 250 mg | 12 wk | — |
Recommended Nicotinamide Mononucleotide products
Real products that dose Nicotinamide Mononucleotide where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.
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Nootropics Depot
NMN Powder
Well dosed 250 mg/day A formulaBrand audit 87/100
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Double Wood Supplements
NMN Nicotinamide Mononucleotide 250 mg
Well dosed 250 mg/day A formulaBrand audit 75/100
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Nootropics Depot
NMN Capsules 250 mg
Well dosed 250 mg/day B formulaBrand audit 87/100
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Nutricost
NMN 1 g
Well dosed 1 Gram(s)/day A formulaBrand audit 57/100
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BulkSupplements.com
NMN (Nicotinamide Mononucleotide)
Well dosed 250 mg/day A formulaBrand audit 54/100
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BulkSupplements.com
NMN
Well dosed 250 mg/day A formulaBrand audit 54/100
Chosen for adequate Nicotinamide Mononucleotide dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.
Risk profile
Adverse events and known drug interactions
Safety events
Drug interactions
Sources
- 1. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. (2019) ↑
- 2. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. (2021) ↑
- 3. A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults. (2022) ↑
- 4. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. (2023) ↑
- 5. Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial. (2023) ↑
- 6. NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease. (2023) ↑
- 7. Oral MIB-626 (β Nicotinamide Mononucleotide) Safely Raises Blood Nicotinamide Adenine Dinucleotide Levels in Hospitalized Patients With COVID-19 and Acute Kidney Injury: A Randomized Controlled Trial. (2025) ↑
- 8. Nicotinamide riboside combined with exercise to treat hypertension in middle-aged and older adults: a pilot randomized clinical trial. (2025) ↑
- 9. Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial. (2025) ↑
- 10. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. (2022) ↑
Generated August 14, 2026
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