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Oroxylum

Oroxylum

What the trials found

Oroxylum shows an early recall signal in healthy adults, but evidence remains too limited to support broad claims about memory, mood, weight, or brain protection.

  • 2 papers
  • 0 of 6 outcomes

Median effective dose, most-studied outcomes

  • Recall information across tasks 500 mg 12 wk
Full protocol, 1 outcomes

Risk, worst reported severity

  • digestive complaints (loose stools, nausea, bloating) mild
  • headache mild
  • doxorubicin moderate
  • cyclophosphamide moderate
All 6 events and interactions
Protocol

Dose, timing & forms

How much

For recall, the available clinical protocol used 500 mg twice daily, totaling 1,000 mg/day, for 12 weeks. 1 That is the only useful human dosing anchor here, so do not assume higher doses improve results or that Oroxylum supports unrelated goals at the same intake. 1

When and how long

The recall research used a consistent twice-daily routine over weeks, which points to regular use rather than taking it only before a test or demanding day. 1 The trial does not establish a best time of day or show that taking it with food changes cognitive effects. 1

Forms & standardisation

Look for an oral product that names Oroxylum indicum and states the extract amount per serving. 1 Human research has not yet established a best flavonoid percentage, baicalein content, or extract ratio, so labels that spotlight one compound do not automatically match the studied preparation. 12

Studied range, by outcome

Outcome Studied range Median effective Duration Evidence
Recall information across tasks 500 mg 500 mg 12 wk 1 paper 4 sig. endpoints

Adverse events and drug interactions

Safety events

digestive complaints (loose stools, nausea, bloating) mild
headache mild
skin rash
adverse effects (unspecified)

Drug interactions

doxorubicin moderate unknown
cyclophosphamide moderate unknown
In context

What this is and how it works

  • One randomized, placebo-controlled trial reported a recall signal in healthy adults, without enough data for a reliable effect-size estimate.1
  • Two papers reviewed here span six outcomes, with human evidence concentrated in a single cognitive-function trial.1
  • Traditional-use and laboratory findings do not establish benefits for broader health outcomes or safe use alongside chemotherapy.2

Oroxylum usually refers to Oroxylum indicum, a flowering tree used in several traditional Asian medicine systems. Its bark, roots, seeds, and pods contain plant compounds called flavonoids, including baicalein and chrysin. 2

Researchers have not established how Oroxylum changes memory in people. Its flavonoids act like tiny switches that influence how brain cells handle stress and send messages in laboratory research, but the human trial measured recall rather than proving that pathway. 12

Bottom line

Oroxylum is worth watching if you want a botanical with an early, specific recall signal and you are comfortable with limited evidence. The current human research does not justify broad promises about memory, mood, weight, or brain protection. People using doxorubicin or cyclophosphamide should avoid self-starting it without guidance because interaction details remain unclear.

Frequently asked

Common questions

What is Oroxylum used for?

Oroxylum is a traditional botanical that researchers are now testing for brain-related outcomes. The small human evidence base examined recall over 12 weeks, not a wide range of consumer benefits. 1

Does Oroxylum improve memory?

Early clinical findings suggest that a specific oral Oroxylum extract improved recall measures in healthy adults. That is promising, but the evidence is still too limited to treat it as a proven memory supplement. 1

How long does Oroxylum take to work?

The available cognitive protocol ran for 12 weeks, so this is not a supplement with evidence for a same-day memory boost. 1

What should I look for in an Oroxylum supplement?

Choose an oral product that clearly identifies Oroxylum indicum and provides the full extract amount per daily serving. Avoid assuming that products with different extraction methods or unlabeled active compounds will perform like the studied extract. 1

Sources

Sources

  1. 1. Oroxylum indicum extract and cognitive function in healthy adults: a randomized, placebo-controlled trial
  2. 2. Oroxylum indicum: traditional uses, phytochemistry, and pharmacology

Generated August 27, 2026

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