Spermidine
Evidence status
Limited evidence to recommend for any consumer outcome yet.
5 papers · 1 claim · 28 outcomes scored
Outcomes
What spermidine actually does, by outcome
Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.
| Outcome | Effect | Evidence | Dose | Weeks | Rank |
|---|---|---|---|---|---|
| Boost your cells' recycling machinery Not enough research | | 3 RCTs n=128 | 0.9–40 mg | 4–52 wk | — |
Recommended Spermidine products
Real products that dose Spermidine where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.
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Double Wood Supplements
Spermidine 10 mg
Well dosed 10 mg/day A formulaBrand audit 75/100
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SuperSmart
Spermidine 3 mg
Well dosed 3 mg/day A formulaBrand audit 63/100
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Dr. Mercola
Fisetin 125 mg and Spermidine
Well dosed 1.2 mg/day B formulaBrand audit 63/100
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Renue By Science
Lipo Spermidine
Well dosed 8 mg/day B formula -
Dr. Emil Nutrition
Spermidine 5 mg
Well dosed 5 mg/day B formula -
Blueprint Bryan Johnson
Essential Capsules
Well dosed 10 mg/day A formula
Chosen for adequate Spermidine dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.
Risk profile
Adverse events and known drug interactions
Safety events
Drug interactions
Sources
- 1. Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. (2018) ↑
- 2. Supplementation of spermidine at 40 mg/day has minimal effects on circulating polyamines: An exploratory double-blind randomized controlled trial in older men. (2024) ↑
- 3. High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study. (2023) ↑
- 4. A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study. (2017) ↑
Generated August 14, 2026
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