Guggul

Best for

Lower bad and total cholesterol

Likely benefit · 2000 mg/day for 8–12 weeks · 1 meta-analysis , n=380

2 papers · 3 claims · 6 outcomes scored · 2 positive

Outcomes

What guggul actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Lower bad and total cholesterol Likely benefit

Cuts the cholesterol that builds into artery plaque over time.

1 meta-analysis n=380 2000 mg 8–12 wk #9/103

34071454

moderate

1 meta-analysis n=380 Meta-analyzed I²=86%

2000 mg

8–12 wk

#9 /103

Raise good cholesterol levels Likely real but unnoticeable

Boosts the cholesterol that pulls fat out of artery walls.

1 meta-analysis n=267 2000 mg 8–12 wk #8/71

34071454

trivial

1 meta-analysis n=267 Meta-analyzed

2000 mg

8–12 wk

#8 /71

Lower triglycerides Probably doesn't help

Reduces the blood fats that rise after meals and drive heart risk.

1 meta-analysis n=352 2000 mg 8–12 wk

34071454

trivial

1 meta-analysis n=352 Meta-analyzed

2000 mg

8–12 wk

—

Outcome	Effect	Evidence	Dose	Weeks	Rank
Lower bad and total cholesterol Likely benefit	moderate	1 meta-analysis n=380 Meta-analyzed	2000 mg	8–12 wk	#9/103
Raise good cholesterol levels Likely real but unnoticeable	trivial	1 meta-analysis n=267 Meta-analyzed	2000 mg	8–12 wk	#8/71
Lower triglycerides Probably doesn't help	trivial	1 meta-analysis n=352 Meta-analyzed	2000 mg	8–12 wk	—

Risk profile

Adverse events and known drug interactions

Safety events

atherosclerosis severe

myocardial infarction severe

hepatotoxicity moderate

alanine aminotransferase increased moderate

gastrointestinal_discomfort mild

severe gastrointestinal upset (led to treatment discontinuation)

abdominal cramp

Inconvenience due to smell of medicine

Drug interactions

Midazolam major increases concentration

Warfarin major decreases effect

other major increases concentration

Rosuvastatin major increases concentration

Lipid Modifying Agents moderate decreases concentration

Diltiazem moderate decreases concentration

Antithrombotic Agents moderate increases toxicity

Sources

Generated August 14, 2026

Guggul

What guggul actually does, by outcome

Adverse events and known drug interactions

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