Reishi mushroom

Best for

Break the insomnia cycle

Promising early signal · 3000 mg/day for 4 weeks · 1 study , n=48

9 papers · 2 claims · 59 outcomes scored · 2 positive

Outcomes

What reishi mushroom actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Break the insomnia cycle Promising early signal

Quiets the nervous-system overdrive that keeps you wired at bedtime.

1 RCT n=48 3000 mg 4 wk #7/14

22203880

moderate

1 RCT n=48

3000 mg

4 wk

#7 /14

Ease fatigue during cancer care Faint early signal

Gives your cells more fuel when treatment is draining everything you have.

1 RCT n=48 3000 mg 4 wk #1/5

22203880

small

1 RCT n=48

3000 mg

4 wk

#1 /5

Outcome	Effect	Evidence	Dose	Weeks	Rank
Break the insomnia cycle Promising early signal	moderate	1 RCT n=48	3000 mg	4 wk	#7/14
Ease fatigue during cancer care Faint early signal	small	1 RCT n=48	3000 mg	4 wk	#1/5

Risk profile

Adverse events and known drug interactions

Safety events

congenital_anomaly severe

stool_disorder mild

Diarrhea

Headache

Migraine

Upset stomach / lower GI

Worsening fatigue

Worsening GERD

Drug interactions

Drug:Warfarin major increases effect

Afatinib major increases concentration

Doxorubicin moderate increases concentration

Paclitaxel moderate increases concentration

Vincristine moderate increases concentration

Docetaxel moderate unknown

Cisplatin moderate unknown

Cyclophosphamide moderate increases effect

Acetaminophen moderate decreases concentration

Gefitinib moderate increases concentration

Sources

Generated August 14, 2026

Reishi mushroom

What reishi mushroom actually does, by outcome

Adverse events and known drug interactions

More evidence for Reishi mushroom

Bitter, Bright, and Patient: When Reishi's 2,000-Year Myth Meets 12-Week Science

Sleep: evidence map across 37 supplements

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Reishi mushroom

More evidence for Reishi mushroom

NewBitter, Bright, and Patient: When Reishi's 2,000-Year Myth Meets 12-Week Science

NewSleep: evidence map across 37 supplements

NewCaffeine

NewCarnitine

NewCoffee

NewCoQ10

Bitter, Bright, and Patient: When Reishi's 2,000-Year Myth Meets 12-Week Science

Sleep: evidence map across 37 supplements

Caffeine

Carnitine

Coffee

CoQ10