Yohimbine

Best for

Feel full longer and crave less

Large effect, needs confirmation · 16.2 mg/day for 1 weeks · 1 study , n=13

16 papers · 7 claims · 38 outcomes scored · 2 positive

Outcomes

What yohimbine actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Feel full longer and crave less Large effect, needs confirmation

Genuine satiety replaces the constant urge to snack or overeat.

1 RCT n=13 16.2 mg 1 wk #3/28

18433425

large

1 RCT n=13

16.2 mg

1 wk

#3 /28

Hold power across repeated sprints Promising early signal

Burst speed and power fade less as efforts stack up.

1 RCT n=36 2.5 mg — #5/14

35162339

moderate

1 RCT n=36

2.5 mg

—

#5 /14

Sharpen focus and mental stamina Early signal of harm

Concentrate longer, resist distraction, and stay mentally sharp through demanding tasks.

2 RCTs n=83 21.6–43.2 mg 0 wk

23559222·26961964

large

2 RCTs n=83

21.6–43.2 mg

0 wk

—

Boost cardiovascular exercise output Early signal of harm

Your heart pushes more blood per beat and sustains higher intensity longer.

1 RCT n=36 2.5 mg —

35162339

large

1 RCT n=36

2.5 mg

—

Blunt blood pressure spikes Early negative signal

Keeps your numbers steadier when stress, caffeine, or exertion hits.

6 RCTs n=167 5.4–43.2 mg 1 wk

20554869·22311903·23161001·23559222 +2 more

moderate

6 RCTs n=167

5.4–43.2 mg

1 wk

—

Lower your blood pressure Early negative signal

Brings down both systolic and diastolic, especially when baseline runs high.

2 RCTs n=97 16.2–20 mg 1 wk

18433425·20554869

moderate

2 RCTs n=97

16.2–20 mg

1 wk

—

Ease your body's stress response Not enough research

Heart rate, sweating, and tension spike less under pressure.

3 RCTs n=201 2.5–10 mg —

35162339·37314480·38123464

—

3 RCTs n=201

2.5–10 mg

—

Outcome	Effect	Evidence	Dose	Weeks	Rank
Feel full longer and crave less Large effect, needs confirmation	large	1 RCT n=13	16.2 mg	1 wk	#3/28
Hold power across repeated sprints Promising early signal	moderate	1 RCT n=36	2.5 mg	—	#5/14
Sharpen focus and mental stamina Early signal of harm	large	2 RCTs n=83	21.6–43.2 mg	0 wk	—
Boost cardiovascular exercise output Early signal of harm	large	1 RCT n=36	2.5 mg	—	—
Blunt blood pressure spikes Early negative signal	moderate	6 RCTs n=167	5.4–43.2 mg	1 wk	—
Lower your blood pressure Early negative signal	moderate	2 RCTs n=97	16.2–20 mg	1 wk	—
Ease your body's stress response Not enough research		3 RCTs n=201	2.5–10 mg	—	—

Buy well

Recommended Yohimbine products

Real products that dose Yohimbine where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Yohimbine dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

seizure severe

poisoning severe

neurotoxicity severe

myocardial injury severe

palpitations

anxiety/tremulousness

hypertension

tachycardia

Drug interactions

Clonidine major increases toxicity

Antidepressants major increases concentration

other major increases concentration

Fluoxetine major increases concentration

Venlafaxine major increases toxicity

other moderate additive

Atenolol moderate decreases effect

Co-studied with

Supplements that share evidence with yohimbine

Drug:Hydrocortisone 3 shared outcomes · d=0.41

Sources

Generated August 14, 2026

Yohimbine

What yohimbine actually does, by outcome

Recommended Yohimbine products

Adverse events and known drug interactions

Supplements that share evidence with yohimbine

More evidence for Yohimbine

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NewCaffeine

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Focus & memory: evidence map across 45 supplements

Caffeine

Fenugreek

Glucomannan

Green Tea

Gymnema