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Vitamin B1

Vitamin B1

Best for

Ease neuropathy pain and numbness

Faint early signal · 300–600 mg/day for 52 weeks · 2 studies , n=51

22 papers · 1 claim · 57 outcomes scored · 1 positive

Outcomes

What vitamin b1 actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Ease neuropathy pain and numbness Faint early signal
small 		2 RCTs n=51 300–600 mg 52 wk #3/7
Buy well

Recommended Vitamin B1 products

Real products that dose Vitamin B1 where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Vitamin B1 dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

urticaria moderate
bronchial_asthma moderate
nausea mild
alanine aminotransferase increased mild
urinary white blood cell positive mild
urinary red blood cell positive mild
proteinuria mild
glomerular filtration rate decreased mild

Drug interactions

Metformin major decreases concentration
Phenformin major decreases concentration
Fedratinib major decreases concentration
Amprolium major decreases concentration
Asparaginase major decreases effect
Cisplatin major decreases effect
Oxaliplatin major decreases effect
Chloroquine moderate decreases concentration
Verapamil moderate decreases concentration
Famotidine moderate decreases concentration

Sources

  1. 1. Effects of benfotiamine treatment over 12 months on morphometric, neurophysiological and clinical measures in type 2 diabetes patients with symptomatic polyneuropathy: a randomized, placebo-controlled, double-blind clinical trial (BOND study). (2026) ↑
  2. 2. A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy. (2010) ↑
  3. 3. The effects of endurance training and thiamine supplementation on anti-fatigue during exercise. (2013) ↑
  4. 4. Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial. (2021) ↑
  5. 5. Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B12 status among young Laotian children: a randomized controlled trial. (2022) ↑
  6. 6. Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy. (2012) ↑
  7. 7. Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence. (2013) ↑
  8. 8. The Effects of Thiamine Supplementation on General Health and Infertility Treatment Outcomes in Women with Polycystic Ovary Syndrome: A Triple-Blinded Randomized Placebo-Controlled Clinical Trial. (2024) ↑
  9. 9. Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity. (2015) ↑
  10. 10. Benfotiamine counteracts smoking-induced vascular dysfunction in healthy smokers. (2012) ↑

Generated August 14, 2026

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