Urolithin A
Evidence status
Limited evidence to recommend for any consumer outcome yet.
7 papers · 0 claims · 32 outcomes scored
Buy well
Recommended Urolithin A products
Real products that dose Urolithin A where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.
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Pure Encapsulations
RENUAL
Well dosed 500 mg/day A formulaBrand audit 78/100
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Codeage
Liposomal Urolithin A
Well dosed 500 mg/day A formula -
Timeline
Longevity Supplement
Well dosed 500 mg/day A formula
Chosen for adequate Urolithin A dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.
Risk profile
Adverse events and known drug interactions
Safety events
myalgia mild
adverse events (any)
genotoxicity (micronucleus formation / DNA strand breaks / topoisomerase II poisoning)
estrogenic activity / endocrine disruption
oxidative stress / increased reactive oxygen species
cellular senescence (after prolonged exposure)
gastrointestinal toxicity (potential / knowledge gap)
All adverse events
Drug interactions
5-Fluorouracil major increases concentration
Cisplatin moderate increases effect
Doxorubicin moderate decreases concentration
Antineoplastic Agents moderate increases effect
Sources
- 1. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. (2022) ↑
- 2. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. (2022) ↑
- 3. Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners. (2025) ↑
- 4. Effect of urolithin A on the improvement of vascular endothelial function depends on the gut microbiota. (2022) ↑
- 5. Effects of Urolithin A supplementation on performance and antioxidant status in academy soccer players during preseason: a pilot randomised controlled trial. (2025) ↑
- 6. Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study. (2024) ↑
- 7. Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial. (2025) ↑
Generated August 14, 2026