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Betaine

Betaine

Evidence status

Limited evidence to recommend for any consumer outcome yet.

32 papers · 0 claims · 84 outcomes scored

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Recommended Betaine products

Real products that dose Betaine where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Betaine dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

cerebral edema / white matter abnormalities severe
cerebral oedema severe
miscarriage severe
stroke severe
bad taste mild
headache mild
gastrointestinal disorder (diarrhea, vomiting, abdominal pain) mild
methionine increased

Drug interactions

Atazanavir moderate increases concentration
Ritonavir moderate increases concentration
OT-58 moderate increases toxicity
Haloperidol moderate decreases effect
Aspirin moderate decreases concentration
Hydrocortisone minor decreases effect

Co-studied with

Supplements that share evidence with betaine

Sources

  1. 1. Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. (2019) ↑
  2. 2. Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine. (2016) ↑
  3. 3. Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery. (2025) ↑
  4. 4. Ergogenic effects of betaine supplementation on strength and power performance. (2010) ↑
  5. 5. Eggs early in complementary feeding increase choline pathway biomarkers and DHA: a randomized controlled trial in Ecuador. (2017) ↑
  6. 6. Plasma Choline Concentration Was Not Increased After a 6-Month Egg Intervention in 6-9-Month-Old Malawian Children: Results from a Randomized Controlled Trial. (2022) ↑
  7. 7. Choline and Betaine Levels in Plasma Mirror Choline Intake in Very Preterm Infants. (2023) ↑
  8. 8. Effects of Two-Week Betaine Supplementation on Apoptosis, Oxidative Stress, and Aerobic Capacity after Exhaustive Endurance Exercise. (2020) ↑
  9. 9. Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial. (2021) ↑
  10. 10. The Effect of 3-Week Betaine Supplementation on Blood Biomarkers of Cardiometabolic Health in Young Physically Active Males. (2022) ↑

Generated August 14, 2026

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