epicatechin
Evidence status
Limited evidence to recommend for any consumer outcome yet.
12 papers · 0 claims · 49 outcomes scored
Risk profile
Adverse events and known drug interactions
Safety events
Platelet count decreased
Alkaline phosphatase decreased
Decreased liver copper concentration
Decreased liver iron concentration
Increased relative kidney weight
nasopharyngitis
dyspepsia
headache
Drug interactions
Amiodarone moderate decreases effect
Levodopa minor decreases concentration
Co-studied with
Supplements that share evidence with epicatechin
- Drug:Simvastatin 11 shared outcomes · d=1.30
Sources
- 1. Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers. (2015) ↑
- 2. A pilot study on clinical pharmacokinetics and preclinical pharmacodynamics of (+)-epicatechin on cardiometabolic endpoints. (2018) ↑
- 3. Beneficial effects of dark chocolate on exercise capacity in sedentary subjects: underlying mechanisms. A double blind, randomized, placebo controlled trial. (2016) ↑
- 4. (-)-Epicatechin Supplementation Inhibits Aerobic Adaptations to Cycling Exercise in Humans. (2018) ↑
- 5. Improving Cardiovascular Risk in Postmenopausal Women with an (-)-Epicatechin-Based Nutraceutical: A Randomly Assigned, Double-Blind vs. Placebo, Proof-of-Concept Trial. (2023) ↑
- 6. Acute (-)-Epicatechin Consumption: Effects on Local Vasodilation Following Resistance Exercise and High-Intensity Exercise Performance. (2020) ↑
- 7. Cardiometabolic Impact of Encapsulated Cocoa Powder and Pure Cocoa Ingredients Supplementation: A Comparative Placebo-Controlled RCT in Adults. (2025) ↑
- 8. Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial. (2026) ↑
- 9. Acute effects of an oral supplement of (-)-epicatechin on postprandial fat and carbohydrate metabolism in normal and overweight subjects. (2014) ↑
- 10. Monomeric Flavanols Are More Efficient Substrates for Gut Microbiota Conversion to Hydroxyphenyl-γ-Valerolactone Metabolites Than Oligomeric Procyanidins: A Randomized, Placebo-Controlled Human Intervention Trial. (2020) ↑
Generated August 14, 2026
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