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Pyrroloquinoline Quinone

Pyrroloquinoline Quinone

Best for

Sharpen focus and mental stamina

Promising early signal · 21.5 mg/day for 12 weeks · 1 study , n=58

23 papers · 2 claims · 108 outcomes scored · 2 positive

Outcomes

What pyrroloquinoline quinone actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Sharpen focus and mental stamina Promising early signal
moderate 		1 RCT n=58 21.5 mg 12 wk —
Speed up thinking and reactions Promising early signal
moderate 		2 RCTs n=58 20–21.5 mg 12 wk #8/28
Buy well

Recommended Pyrroloquinoline Quinone products

Real products that dose Pyrroloquinoline Quinone where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Pyrroloquinoline Quinone dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

fatigue mild
dizziness mild
urticaria mild
headache mild
loose stool mild
diarrhea mild
stomach discomfort mild
palpitation mild

Drug interactions

Clozapine moderate additive
Blood Glucose Lowering moderate unknown
Lipid Modifying Agents moderate unknown

Co-studied with

Supplements that share evidence with pyrroloquinoline quinone

Sources

  1. 1. Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. (2022) ↑
  2. 2. Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults. (2023) ↑
  3. 3. Effects of Pyrroloquinoline Quinone (PQQ) Supplementation on Aerobic Exercise Performance and Indices of Mitochondrial Biogenesis in Untrained Men. (2020) ↑
  4. 4. Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD. (2022) ↑
  5. 5. Dietary pyrroloquinoline quinone hinders aging progression in male mice and D-galactose-induced cells. (2024) ↑
  6. 6. Effects of Pyrroloquinoline Quinone on Lipid Metabolism and Anti-Oxidative Capacity in a High-Fat-Diet Metabolic Dysfunction-Associated Fatty Liver Disease Chick Model. (2021) ↑
  7. 7. Pyrroloquinoline quinone protects against murine hepatitis virus strain 3-induced fulminant hepatitis by inhibiting the Keap1/Nrf2 signaling. (2024) ↑
  8. 8. PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3β/Akt signaling pathway in mouse. (2018) ↑
  9. 9. Effects of Diet Supplemented with Excess Pyrroloquinoline Quinone Disodium on Growth Performance, Blood Parameters and Redox Status in Weaned Pigs. (2021) ↑
  10. 10. Dietary Pyrroloquinoline Quinone Addition Alleviated Weaning Stress via Modulation of Gut Microbiota and Metabolic Profiles in Weaned Piglets. (2025) ↑

Generated August 14, 2026

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