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Phosphatidylserine

Phosphatidylserine

Best for

Ease ADHD symptoms in children

Promising early signal · 200–300 mg/day for 8 weeks · 1 meta-analysis , n=252

13 papers · 3 claims · 46 outcomes scored · 3 positive

Outcomes

What phosphatidylserine actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Ease ADHD symptoms in children Promising early signal
moderate 		2 meta-analyses n=252 Meta-analyzed 200–300 mg 8 wk #2/3
Reduce daily stress Faint early signal
small 		7 RCTs n=92 200–800 mg 1–6 wk —
Strengthen your memory Barely detectable
trivial 		4 RCTs n=273 100–300 mg 8–26 wk —
Buy well

Recommended Phosphatidylserine products

Real products that dose Phosphatidylserine where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Phosphatidylserine dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

tenesmus moderate
cholinergic_toxicity moderate
tachycardia moderate
hyperhidrosis moderate
nausea moderate
gastrointestinal discomfort mild
headache_and_dizziness mild
aches and pains mild

Co-studied with

Supplements that share evidence with phosphatidylserine

Sources

  1. 1. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. (1992) ↑
  2. 2. Effects of phosphatidylserine on oxidative stress following intermittent running. (2005) ↑
  3. 3. Phosphatidylserine supplementation and recovery following downhill running. (2006) ↑
  4. 4. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. (2008) ↑
  5. 5. The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise. (2011) ↑
  6. 6. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. (2010) ↑
  7. 7. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. (2010) ↑
  8. 8. The cognitive effects of supplementation with sunflower phosphatidyl serine in healthy children aged 8 to 12 years: a randomized controlled trial. (2025) ↑
  9. 9. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. (2001) ↑
  10. 10. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. (2014) ↑

Generated August 14, 2026

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