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Resveratrol

Resveratrol

Best for

Reduce fine lines and wrinkles

Promising early signal · 150 mg/day for 8 weeks · 1 study , n=60

71 papers · 5 claims · 180 outcomes scored · 5 positive

Evidence summary

Evidence summary

Likely modest benefit

Resveratrol likely modest benefit for blood pressure in adults, with smaller hints of vascular support and early skin-aging signals, but no dramatic anti-aging reset.

  • Across 15 studies (n=4,025), resveratrol lowered blood pressure, the strongest human signal in the set.2
  • The research footprint spans 71 papers and 180 outcomes, with one promising endothelial-function tier and three early claims.
  • Human trials vary widely in dose, duration, and formulation, which keeps the evidence uneven across outcomes.

Outcomes

What resveratrol actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Reduce fine lines and wrinkles Promising early signal

Smooths crow's feet, forehead lines, and surface roughness.

1 study n=60 150 mg 8 wk #4/5
41488277
Lower your blood pressure Likely modest benefit

Brings down both systolic and diastolic, especially when baseline runs high.

15 meta-analyses n=4.0k 8.1–3000 mg 4–14 wk
22055504·23193181·24073011·24866496 +11 more
Lower bad and total cholesterol Studies contradict

Cuts the cholesterol that builds into artery plaque over time.

20 meta-analyses n=8.8k 10–3000 mg/kg 4–26 wk #7/104
24073011·27560482·28329397·28505227 +16 more
Slow biological aging markers Not enough research

Your body's internal age trends younger than the calendar predicts.

2 meta-analyses n=632 40–3000 mg 14–26 wk #1/2
29330620·40158656
Keep arteries flexible Not enough research

Artery walls that stretch and recoil absorb each heartbeat smoothly.

3 RCTs n=138 150–500 mg 4–4 wk
28604618·34073163·37447275

Forms & standardisation

Look for trans-resveratrol on the label, not just 'polyphenols' or a vague red-wine blend. The human literature mostly uses purified trans-resveratrol or a standardized extract, often from Japanese knotweed or grape sources, so the milligram number on the label should match the active form you are actually getting.13

Risk profile

Adverse events and known drug interactions

Safety events

nephrotoxicity severe
Nephrotoxicity severe
Cardiac inflammation severe
Renal tubular necrosis severe
Urinary tract infection (hospitalisation) severe
Bowel blockage (hospitalisation) severe
Oesophageal tear repair (hospitalisation) severe
Pre-scheduled lumbar spine operation (hospitalisation) severe

Drug interactions

Paclitaxel major decreases effect
Cyclosporine major increases concentration
Midazolam major increases concentration
Drug:Warfarin major increases effect
Antidepressants major increases toxicity
other major increases effect
Warfarin major increases effect
Methotrexate major increases concentration
other major decreases effect
Bortezomib major unknown

Co-studied with

Supplements that share evidence with resveratrol

Quercetin 18 shared outcomes · d=0.55
Vitamind 9 shared outcomes · d=0.32
Thyme 9 shared outcomes · d=1.88

Frequently asked

Common questions

Does resveratrol lower blood pressure?

Yes, but the effect stays modest. The clearest signals show up when blood pressure starts higher, and the trials usually use daily dosing for several weeks.2

How long does resveratrol take to work?

Most human studies run 4–8 weeks before they check outcomes like blood pressure or artery function, so that is the earliest honest window to look for a change.13

What form of resveratrol should you buy?

Buy a product that clearly lists trans-resveratrol and the active milligrams. Vague blends hide the part researchers actually tested.1

Does resveratrol reduce wrinkles?

Early research says yes in a small way, with one study reporting smoother skin after 8 weeks, but the evidence stays thin.4

Track resveratrol in the app

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Sources

  1. 1. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism in obese humans (2011) ↑
  2. 2. Resveratrol blood pressure randomized trials meta-analysis
  3. 3. Resveratrol endothelial function randomized trials meta-analysis
  4. 4. Resveratrol wrinkles photoaging trial

Generated May 15, 2026

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