Satiereal

Best for

Stay asleep through the night

Likely benefit for 5–6 weeks · 1 meta-analysis , n=292

44 papers · 10 claims · 109 outcomes scored · 8 positive

Outcomes

What satiereal actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Stay asleep through the night Likely benefit

Fewer wake-ups and more unbroken hours of real rest.

2 meta-analyses n=292 0.6–300 mg 5–6 wk #2/15

36141931·33925432

moderate

2 meta-analyses n=292 Meta-analyzed

0.6–300 mg

5–6 wk

#2 /15

Lower day-to-day anxiety Faint early signal

The background hum of worry that colors everything gets quieter.

3 meta-analyses n=191 0.6–300 mg 1–5 wk #9/48

34745923·36141931·37288021

small

3 meta-analyses n=191 Meta-analyzed

0.6–300 mg

1–5 wk

#9 /48

Ease anxiety in older adults Faint early signal

Quiets the health worries and body tension that build with age.

3 meta-analyses n=191 0.6–300 mg 1–5 wk #9/45

34745923·36141931·37288021

small

3 meta-analyses n=191 Meta-analyzed

0.6–300 mg

1–5 wk

#9 /45

Reduce pre-competition anxiety Faint early signal

Quiets the overthinking that hijacks execution right before you compete.

3 meta-analyses n=191 0.6–300 mg 1–5 wk #9/45

34745923·36141931·37288021

small

3 meta-analyses n=191 Meta-analyzed

0.6–300 mg

1–5 wk

#9 /45

Reduce daily stress Faint early signal

Everyday pressure stops running your nervous system hot.

2 RCTs n=19 0.06–30 mg 8 wk

33598475·37447245

small

2 RCTs n=19

0.06–30 mg

8 wk

—

Ease depression symptoms Proven but unnoticeable

Lowers the weight of sadness, low energy, and emotional numbness over weeks.

9 meta-analyses n=18k 0.6–300 mg 4–48 wk #2/41

22552758·23280545·24299602·29849461 +5 more

trivial

9 meta-analyses n=18k Meta-analyzed I²=94%

0.6–300 mg

4–48 wk

#2 /41

Ease winter depression symptoms Proven but unnoticeable

Compensates for the sunlight deficit when days get short.

8 meta-analyses n=18k 15–125 mg 4–48 wk #2/39

22552758·23280545·24299602·29849461 +4 more

trivial

8 meta-analyses n=18k Meta-analyzed I²=94%

15–125 mg

4–48 wk

#2 /39

Ease depression tied to chronic pain Proven but unnoticeable

When pain loosens its grip, mood follows.

8 meta-analyses n=18k 15–125 mg 4–48 wk #2/39

22552758·23280545·24299602·29849461 +4 more

trivial

8 meta-analyses n=18k Meta-analyzed I²=94%

15–125 mg

4–48 wk

#2 /39

Improve everyday quality of life Not enough research

Fewer days where health problems dictate what you can and cannot do.

1 RCT n=— 15.5 mg 6 wk

33925432

—

1 RCT n=—

15.5 mg

6 wk

—

Reduce everyday pain intensity Not enough research

Lower intensity, fewer flares, and longer stretches of relief.

1 meta-analysis n=— 100 mg 12 wk #10/55

33322318

—

1 meta-analysis n=— Meta-analyzed

100 mg

12 wk

#10 /55

Outcome	Effect	Evidence	Dose	Weeks	Rank
Stay asleep through the night Likely benefit	moderate	2 meta-analyses n=292 Meta-analyzed	0.6–300 mg	5–6 wk	#2/15
Lower day-to-day anxiety Faint early signal	small	3 meta-analyses n=191 Meta-analyzed	0.6–300 mg	1–5 wk	#9/48
Ease anxiety in older adults Faint early signal	small	3 meta-analyses n=191 Meta-analyzed	0.6–300 mg	1–5 wk	#9/45
Reduce pre-competition anxiety Faint early signal	small	3 meta-analyses n=191 Meta-analyzed	0.6–300 mg	1–5 wk	#9/45
Reduce daily stress Faint early signal	small	2 RCTs n=19	0.06–30 mg	8 wk	—
Ease depression symptoms Proven but unnoticeable	trivial	9 meta-analyses n=18k Meta-analyzed	0.6–300 mg	4–48 wk	#2/41
Ease winter depression symptoms Proven but unnoticeable	trivial	8 meta-analyses n=18k Meta-analyzed	15–125 mg	4–48 wk	#2/39
Ease depression tied to chronic pain Proven but unnoticeable	trivial	8 meta-analyses n=18k Meta-analyzed	15–125 mg	4–48 wk	#2/39
Improve everyday quality of life Not enough research		1 RCT n=—	15.5 mg	6 wk	—
Reduce everyday pain intensity Not enough research		1 meta-analysis n=— Meta-analyzed	100 mg	12 wk	#10/55

Buy well

Recommended Satiereal products

Real products that dose Satiereal where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Satiereal dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

angina severe

COVID-19 severe

diverticulitis severe

headache mild

nausea mild

decreased appetite mild

increased appetite mild

sedation mild

Sources

Generated August 14, 2026

Evidence map
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