Aloe vera

Evidence status

Limited evidence to recommend for any consumer outcome yet.

16 papers · 2 claims · 24 outcomes scored

Outcomes

What aloe vera actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Boost skin hydration Early signal of harm

Locks more moisture into skin so it feels softer and less tight.

1 study n=46 — 4 wk

24991119

large

1 study n=46

—

4 wk

—

Improve overall digestive comfort Not enough research

Less cramping, rumbling, and unease throughout your gut.

1 RCT n=— 60 mL —

21991499

—

1 RCT n=—

60 mL

—

Outcome	Effect	Evidence	Dose	Weeks	Rank
Boost skin hydration Early signal of harm	large	1 study n=46	—	4 wk	—
Improve overall digestive comfort Not enough research		1 RCT n=—	60 mL	—	—

Risk profile

Adverse events and known drug interactions

Safety events

hepatotoxicity severe

Drug interactions

Digoxin major increases toxicity

Antithrombotic Agents moderate increases toxicity

Sources

Generated August 14, 2026

Aloe vera

What aloe vera actually does, by outcome

Adverse events and known drug interactions

More evidence for Aloe vera

The Leaf That Heals—and Warns: Aloe Vera's Journey from Temple Walls to Clinical Trials

Metabolic health: evidence map across 82 supplements

Bacillus Coagulans

Black Seed

Brown Seaweed and Kelp

chicory

Aloe vera

More evidence for Aloe vera

NewThe Leaf That Heals—and Warns: Aloe Vera's Journey from Temple Walls to Clinical Trials

NewMetabolic health: evidence map across 82 supplements

NewBacillus Coagulans

NewBlack Seed

NewBrown Seaweed and Kelp

Newchicory

The Leaf That Heals—and Warns: Aloe Vera's Journey from Temple Walls to Clinical Trials

Metabolic health: evidence map across 82 supplements

Bacillus Coagulans

Black Seed

Brown Seaweed and Kelp

chicory