Vitex

Best for

Make periods more regular

Large effect, needs confirmation · 5.8 mg/day for 12 weeks · 1 study , n=60

3 papers · 3 claims · 23 outcomes scored · 3 positive

Outcomes

What vitex actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Make periods more regular Large effect, needs confirmation

Brings skipped or unpredictable cycles closer to a monthly rhythm.

1 RCT n=60 5.8 mg 12 wk #1/3

41428718

large

1 RCT n=60

5.8 mg

12 wk

#1 /3

Ease the full menopause symptom load Large effect, needs confirmation

Less joint pain, fewer palpitations, and cooler nights.

1 RCT n=52 60 mg 8 wk #2/13

31067851

large

1 RCT n=52

60 mg

8 wk

#2 /13

Ease cyclical breast tenderness Likely benefit

Hormonal soreness fades so you stop dreading each cycle.

1 meta-analysis n=— — — #1/4

36446563

moderate

1 meta-analysis n=— Meta-analyzed

—

#1 /4

Outcome	Effect	Evidence	Dose	Weeks	Rank
Make periods more regular Large effect, needs confirmation	large	1 RCT n=60	5.8 mg	12 wk	#1/3
Ease the full menopause symptom load Large effect, needs confirmation	large	1 RCT n=52	60 mg	8 wk	#2/13
Ease cyclical breast tenderness Likely benefit	moderate	1 meta-analysis n=— Meta-analyzed	—	—	#1/4

Risk profile

Adverse events and known drug interactions

Safety events

Acne mild

Headache mild

Spotting mild

Gastrointestinal disorder mild

Nausea mild

Fatigue mild

Dry mouth mild

Erythematous rash mild

Sources

Generated August 14, 2026

Vitex

What vitex actually does, by outcome

Adverse events and known drug interactions

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